호모사피엔스 종의 단백질 코딩 유전자
칼슘/칼모둘린 의존 단백질 키나아제 타입 IV 는 인간에서 CAMK4 유전자 에 의해 암호화된 효소 다.[5]
이 유전자의 산물은 세린/트레오닌 단백질 키나아제 계열과 Ca2+ /calmodulin 의존성 단백질 키나제 (CAMK) 하위 계열에 속한다. 이 효소는 림프구 , 뉴런 , 남성 세균 세포 의 전사적 조절에 관여해 온 조직 분포가 제한된 다기능 세린/트레오닌 단백질 키나아제다.[6]
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"A unique phosphorylation-dependent mechanism for the activation of Ca2+ /calmodulin-dependent protein kinase type IV/GR" . J. Biol. Chem . 271 (35): 21542–8. doi :10.1074/jbc.271.35.21542 PMID 8702940 . Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+ /calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18" . Mol. Cell. Biol . 17 (6): 3459–67. doi :10.1128/mcb.17.6.3459 . PMC 232199 PMID 9154845 . Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+ / calmodulin-dependent protein kinase I by calmodulin and by Ca2+ /calmodulin-dependent protein kinase kinase" . J. Biol. Chem . 273 (34): 21473–81. doi :10.1074/jbc.273.34.21473 PMID 9705275 . Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. 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