DAPK3
DAPK3| DAPK3 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | DAPK3, DLK, ZIP, ZIPK, 사망관련 단백질키나제3, 사망관련 단백질키나제3 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 603289 MGI: 1203520 호몰로진: 20353 GeneCard: DAPK3 | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레스 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Cr 19: 3.96 – 3.97Mb | Chr 10: 81.02 – 81.03Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
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죽음과 관련된 단백질 키나아제 3은 인간에게 DAPK3 유전자에 의해 암호화된 효소다.[5][6]
함수
죽음과 관련된 단백질 키나아제 3(DAPK3)는 포유류 세포에서 과압 시 세포사멸의 형태학적 변화를 유도한다.이러한 결과는 DAPK3가 사멸을 유도하는 역할을 할 수 있음을 시사한다.[6]
대부분의 다른 포유류 유전자와 달리, 머린(쥐와 쥐) DAPK3는 가속화된 진화를 거쳤고 물고기에서 인간으로 유지되는 긴밀하게 보존된 합의에서 벗어났다.[7]
상호작용
DAPK3는 PAWR[8] 및 Death 관련 단백질 6과 상호작용하는 것으로 나타났다.[8]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000167657 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000034974 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
- ^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3".
- ^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
- ^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
추가 읽기
- Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization". Journal of Human Genetics. 43 (3): 209–11. doi:10.1007/s100380050073. PMID 9747039.
- Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H (May 1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters. 451 (1): 81–4. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987. S2CID 43329315.
- Page G, Lödige I, Kögel D, Scheidtmann KH (Nov 1999). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters. 462 (1–2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. S2CID 6061613.
- Page G, Kögel D, Rangnekar V, Scheidtmann KH (Dec 1999). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene. 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
- Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF (Oct 2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Molecular and Cellular Biology. 22 (20): 6959–70. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
- Preuss U, Landsberg G, Scheidtmann KH (Feb 2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research. 31 (3): 878–85. doi:10.1093/nar/gkg176. PMC 149197. PMID 12560483.
- Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
- Burch LR, Scott M, Pohler E, Meek D, Hupp T (Mar 2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology. 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
- Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME (Oct 2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase". The Journal of Biological Chemistry. 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
- Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. S2CID 17142907.
- Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L (Jun 2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3". International Journal of Andrology. 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
- Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
- Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M (Dec 2006). "Novel ZIP kinase isoform lacks leucine zipper". Archives of Biochemistry and Biophysics. 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMC 2758612. PMID 17126281.
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