SGK3
SGK3| SGK3 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | SGK3, CISK, SGK2, SGKL, 혈청/글루코르티코이드 규제 키나아제 가족 구성원 3 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 607591 MGI: 2182368 HomoloGene: 56582 GeneCard: SGK3 | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Chr 8: 66.71 – 66.86Mb | Chr 1: 9.87 – 9.97Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
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세린/스레오닌-단백질 키나아제 Sgk3는 인간에서 SGK3 유전자에 의해 암호화된 효소다.[5][6][7]
함수
이 유전자는 세린/트레오닌 단백질 키나아제 계열의 일원으로 PX(phox homology) 도메인으로 인광프로테인을 인코딩한다.단백질 인산염은 여러 표적 단백질을 생성하며, 중성 아미노산 운반과 칼륨 및 염화물 채널의 활성화에 역할을 한다.다른 ISO 양식을 인코딩하는 대체 전사 스플라이스 변형이 특징지어졌다.[7]
멜라노사이트 세포에서는 SGK3 유전자 발현이 MITF에 의해 조절될 수 있다.[8]
상호작용
SGK3는 GSK3B와 상호작용하는 것으로 나타났다.[9]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000104205 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000025915 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
- ^ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
- ^ a b "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
- ^ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
추가 읽기
- Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
- Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. Bibcode:2000PNAS...9711960F. doi:10.1073/pnas.220413597. PMC 17277. PMID 11035810.
- Xu J, Liu D, Gill G, Songyang Z (2001). "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. doi:10.1083/jcb.200105089. PMC 2196448. PMID 11514587.
- Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi:10.1074/jbc.M107768200. PMID 11751930.
- Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB (2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway". Mol. Cell. Biol. 22 (7): 2099–110. doi:10.1128/MCB.22.7.2099-2110.2002. PMC 133668. PMID 11884598.
- Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
- Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. doi:10.1074/jbc.M207604200. PMID 12218062.
- Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
- Henke G, Setiawan I, Böhmer C, Lang F (2003). "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. doi:10.1159/000068699. PMID 12590200. S2CID 30241243.
- Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
- Embark HM, Böhmer C, Vallon V, Luft F, Lang F (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
- Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S (2004). "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. doi:10.1074/jbc.M309653200. PMID 14604990.
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