TOLLIP 라고도 알려진 TOL 상호 작용 단백질은 TOLLIP 유전자에 [5] [6] [7] 어댑터 단백질 이다.
기능. Toll-like 수용체(TLR)[8] TLR 경로는 구조적으로 보존된 미생물 병원체의 분자 패턴을 인식하는 선천적 면역 시스템 의 일부이며, 염증성 면역 반응을 이끈다.
임상적 의의 TLR 유전자의 다형성 은 아토피 와 [9] 같은 다양한 질병과 관련이 있다. 최근 TOLLIP 유전자의 변이가 결핵과 특발성 [10] [11]
상호 작용 TOLLIP는 TOM1,[12] TLR [13] TLR [13] IL1RAP 과 [7] 상호 작용하는 것으로 나타났습니다 .
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000078902 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025139 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: TOLLIP toll interacting protein" .^ Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Letters . 419 (1): 41–4. doi :10.1016/S0014-5793(97)01426-9 . PMID 9426216 . S2CID 39772937 . ^ a b Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology . 2 (6): 346–51. doi :10.1038/35014038 . PMID 10854325 . S2CID 32036101 . ^ Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling" . Journal of Immunology . 167 (2): 987–94. doi :10.4049/jimmunol.167.2.987 PMID 11441107 . ^ Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S (March 2007). "Association of toll-interacting protein gene polymorphisms with atopic dermatitis" . BMC Dermatology . 7 : 3. doi :10.1186/1471-5945-7-3 . PMC 1832210 PMID 17362526 . ^ Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, et al. (August 2012). "Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis" . Journal of Immunology . 189 (4): 1737–46. doi :10.4049/jimmunol.1103541 . PMC 3428135 PMID 22778396 . ^ Gilgenkrantz S, Droulle P, Schweitzer M, Foliguet B, Gérard H, Plénat F (June 1985). "[Prenatal diagnosis of triploidy. I. Echographic, clinical and anatomic studies]" . Journal de Génétique Humaine . 33 (2): 143–52. doi :10.1016/S2213-2600(13)70045-6 . PMC 3894577 PMID 24429156 . ^ Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin" . The Journal of Biological Chemistry . 278 (52): 52865–72. doi :10.1074/jbc.M306740200 PMID 14563850 . ^ a b Zhang G, Ghosh S (March 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip" . The Journal of Biological Chemistry . 277 (9): 7059–65. doi :10.1074/jbc.M109537200 PMID 11751856 .
추가 정보 Nilsen KH (May 1976). "Malignant lymphoma and rheumatic symptoms". The New Zealand Medical Journal . 83 (563): 320–2. PMID 1085432 . Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Letters . 419 (1): 41–4. doi :10.1016/S0014-5793(97)01426-9 . PMID 9426216 . S2CID 39772937 . Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology . 2 (6): 346–51. doi :10.1038/35014038 . PMID 10854325 . S2CID 32036101 . Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling" . Journal of Immunology . 167 (2): 987–94. doi :10.4049/jimmunol.167.2.987 PMID 11441107 . Zhang G, Ghosh S (March 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip" . The Journal of Biological Chemistry . 277 (9): 7059–65. doi :10.1074/jbc.M109537200 PMID 11751856 . Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin" . The Journal of Biological Chemistry . 278 (52): 52865–72. doi :10.1074/jbc.M306740200 PMID 14563850 . Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (June 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes" . The Journal of Biological Chemistry . 279 (23): 24435–43. doi :10.1074/jbc.M400059200 PMID 15047686 . Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Research . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, et al. (September 2005). "CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells" . Molecular and Cellular Biology . 25 (17): 7743–57. doi :10.1128/MCB.25.17.7743-7757.2005 . PMC 1190283 PMID 16107720 . Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006" . Nucleic Acids Research . 34 (Database issue): D415-8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Katoh Y, Imakagura H, Futatsumori M, Nakayama K (March 2006). "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex". Biochemical and Biophysical Research Communications . 341 (1): 143–9. doi :10.1016/j.bbrc.2005.12.156 . PMID 16412388 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Brissoni B, Agostini L, Kropf M, Martinon F, Swoboda V, Lippens S, et al. (November 2006). "Intracellular trafficking of interleukin-1 receptor I requires Tollip" . Current Biology . 16 (22): 2265–70. doi :10.1016/j.cub.2006.09.062 PMID 17113392 . S2CID 13938932 .
PDB 갤러리
1wgl : 인체 통행료 상호작용단백질(Tollip)의 C-말단 CUE 도메인 용액구조
