ITGAE

ITGAE
식별자
별칭	ITGAE, CD103, HUMINAE, 서브유닛 알파 E 통합
외부 ID	OMIM: 604682 MGI: 1298377 호몰로Gene: 113560 GeneCard: ITGAE
유전자 위치(인간)
쳇.	17번 염색체(인간)
끝	3,801,190 bp
유전자 위치(마우스)
쳇.	11번 염색체(쥐)
끝	73,038,272 bp
RNA 표현 패턴
	표현된 상단
	입자핵; ; 삼두근.; ; 흑인의 실체; ; 지방 조직; ; 복부 지방; ; 델토이드 근육; ; 이두박근 브라치이; ; 보석을 깔다;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	금속 이온 결합;
셀룰러 컴포넌트	막의 적분 성분; 집적 복합체; 플라즈마 막; 플라즈마 막의 외부 면; 막으로 막다;
생물학적 과정	통합 매개 신호 경로; 세포 접착; 세포외 매트릭스 조직;
	출처:아미고 / 퀵고
직교체
	3682
	16407
	ENSG00000083457
	ENSMUSG00000005947
	P38570
	Q60677
	NM_002208
	NM_008399; NM_172944; NM_001361245
	NP_002199
	NP_032425; NP_001348174
	위키다타
인간 보기/편집	마우스 보기/편집

CD103(분화 103)으로도 알려진 Integin, 알파 E(ITGAE)는 인간에서 ITGAE 유전자에 의해 인코딩되는 통합 단백질이다.^[5]^[6]CD103은 integin 베타 7(β7– ITGB7)을 결합하여 별개의 이름이 없는 완전한 이질적 αEβ7 분자를 형성한다.αEβ7 복합체를 흔히 "CD103"이라고 부르지만, 이는 αE 체인만을 엄격히 지칭한다.β7 서브유닛은 α4(CD49d)와 같은 다른 통합 α 체인과 결합할 수 있다는 점에 유의한다.

조직 분포

CD103은 세포내 림프구(IEL) T세포(αβ T세포와 Δ T세포 모두)와 일부 주변 규제 T세포(Tregs)에 광범위하게 표현된다.^[7]라미나 프로프리아 T세포에도 보고됐다.^[8]CD103 덴드리트 세포로 알려진 장 점막과 중간 림프절의 부분집합도 이 표식을 나타낸다.^[9]

장막병증 관련 T세포 림프종을 제외한 CD103에 음성인 다른 대부분의 혈액학적 악성종과는 대조적으로 이 표지에 양성인 털이 많은 세포 백혈병을 식별하는 데 유용하다.^[10]

함수

αEβ7의 수석 리간드는 상피세포에서 발견된 세포접착분자(CAM)인 E-cadherin이다.^[11]그것은 아마도 장내 부위로의^[12] T세포와 흉선세포와의 흉선세포 접촉에 있어서 중요할 것이다.^[13]

트레그는 면역 반응을 감소시키는데 중요하며 자가면역질환 예방에 중요한 역할을 하는 것으로 보인다.Tregs는 CD4⁺/CD25⁺/Foxp3⁺ 셀로 정의된다.^[14]일부 CD4⁺/FoxP3⁻ 셀은 CD103을 표현하기도 하며 규제 활동으로 간주되어 왔다.Treg 셀에 CD103이 존재한다는 것이 Treg를 위한 특화된 특징인지, IEL T 셀의 Treg 분화를 나타내는 것인지는 불분명하다.

참고 항목

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG000083457 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000005947 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249.
^ "Entrez Gene: integrin".
^ Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A (October 2002). "Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13031–6. Bibcode:2002PNAS...9913031L. doi:10.1073/pnas.192162899. PMC 130581. PMID 12242333.
^ Aziz S, Fackler OT, Meyerhans A, Müller-Lantzsch N, Zeitz M, Schneider T (January 2005). "Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa". J. Acquir. Immune Defic. Syndr. 38 (1): 23–30. doi:10.1097/00126334-200501010-00005. PMID 15608520. S2CID 22884381.
^ Johansson-Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Förster R, Agace WW (October 2005). "Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing". J. Exp. Med. 202 (8): 1063–73. doi:10.1084/jem.20051100. PMC 2213212. PMID 16216890.
^ Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (World Health Organization Classification of Tumours) (4th ed.). Geneva: World Health Organization. ISBN 978-92-832-2431-0.
^ Hadley GA, Bartlett ST, Via CS, Rostapshova EA, Moainie S (October 1997). "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL". J. Immunol. 159 (8): 3748–56. PMID 9378961.
^ Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM (October 2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. doi:10.1016/S0955-0674(00)00132-0. PMID 10978890.
^ Kutleša, Snježana; Wessels, Johannes T.; Speiser, Angelika; Steiert, Inge; Müller, Claudia A.; Klein, Gerd (2002-12-01). "E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation". Journal of Cell Science. 115 (23): 4505–4515. doi:10.1242/jcs.00142. ISSN 1477-9137.
^ Allakhverdi Z, Fitzpatrick D, Boisvert A, Baba N, Bouguermouh S, Sarfati M, Delespesse G (December 2006). "Expression of CD103 identifies human regulatory T-cell subsets". J. Allergy Clin. Immunol. 118 (6): 1342–9. doi:10.1016/j.jaci.2006.07.034. PMID 17137867.

추가 읽기

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Tilburgs T, Scherjon SA, Roelen DL, Claas FH (2009). "Decidual CD8+CD28- T cells express CD103 but not perforin". Hum. Immunol. 70 (2): 96–100. doi:10.1016/j.humimm.2008.12.006. PMID 19150377.
Schlickum S, Sennefelder H, Friedrich M, et al. (2008). "Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion". Blood. 112 (3): 619–25. doi:10.1182/blood-2008-01-134833. PMID 18492951.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Liu YH, Chen RH, Chen WC, et al. (2010). "Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients". Ophthalmology. 117 (8): 1645–51. doi:10.1016/j.ophtha.2009.12.037. PMID 20417566.
Lesch KP, Timmesfeld N, Renner TJ, et al. (2008). "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies". J Neural Transm. 115 (11): 1573–85. doi:10.1007/s00702-008-0119-3. PMID 18839057. S2CID 7036114.
Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
Agace WW, Higgins JM, Sadasivan B, et al. (2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. doi:10.1016/S0955-0674(00)00132-0. PMID 10978890.
Hadley G (2004). "Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells". Am. J. Transplant. 4 (7): 1026–32. doi:10.1111/j.1600-6143.2004.00465.x. PMID 15196058. S2CID 3038018.
Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
Annacker O, Coombes JL, Malmstrom V, et al. (2005). "Essential role for CD103 in the T cell-mediated regulation of experimental colitis". J. Exp. Med. 202 (8): 1051–61. doi:10.1084/jem.20040662. PMC 2213206. PMID 16216886.
Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249.
Uss E, Rowshani AT, Hooibrink B, et al. (2006). "CD103 is a marker for alloantigen-induced regulatory CD8+ T cells". J. Immunol. 177 (5): 2775–83. doi:10.4049/jimmunol.177.5.2775. PMID 16920912.
Le Floc'h A, Jalil A, Vergnon I, et al. (2007). "Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis". J. Exp. Med. 204 (3): 559–70. doi:10.1084/jem.20061524. PMC 2137907. PMID 17325197.
Heron M, Grutters JC, Van Moorsel CH, et al. (2009). "Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography". Clin. Immunol. 133 (1): 117–25. doi:10.1016/j.clim.2009.06.007. PMID 19604725.
Shaw SK, Brenner MB (1995). "The beta 7 integrins in mucosal homing and retention". Semin. Immunol. 7 (5): 335–42. doi:10.1016/1044-5323(95)90014-4. PMID 8580465.
Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. doi:10.1007/s000180050184. PMID 9676575. S2CID 9775686.
Heron M, Slieker WA, Zanen P, et al. (2008). "Evaluation of CD103 as a cellular marker for the diagnosis of pulmonary sarcoidosis". Clin. Immunol. 126 (3): 338–44. doi:10.1016/j.clim.2007.11.005. PMID 18182176.

외부 링크

ITGAE+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MesH)
셀 마이그레이션 게이트웨이에 링크가 있는 ITGAE 정보

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG000083457 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000005947 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12370249-5] Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249.

[entrez-6] "Entrez Gene: integrin".

[pmid12242333-7] Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A (October 2002). "Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13031–6. Bibcode:2002PNAS...9913031L. doi:10.1073/pnas.192162899. PMC 130581. PMID 12242333.

[pmid15608520-8] Aziz S, Fackler OT, Meyerhans A, Müller-Lantzsch N, Zeitz M, Schneider T (January 2005). "Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa". J. Acquir. Immune Defic. Syndr. 38 (1): 23–30. doi:10.1097/00126334-200501010-00005. PMID 15608520. S2CID 22884381.

[pmid16216890-9] Johansson-Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Förster R, Agace WW (October 2005). "Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing". J. Exp. Med. 202 (8): 1063–73. doi:10.1084/jem.20051100. PMC 2213212. PMID 16216890.

[isbn92-832-2431-0-10] Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (World Health Organization Classification of Tumours) (4th ed.). Geneva: World Health Organization. ISBN 978-92-832-2431-0.

[pmid9378961-11] Hadley GA, Bartlett ST, Via CS, Rostapshova EA, Moainie S (October 1997). "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL". J. Immunol. 159 (8): 3748–56. PMID 9378961.

[pmid10978890-12] Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM (October 2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. doi:10.1016/S0955-0674(00)00132-0. PMID 10978890.

[13] Kutleša, Snježana; Wessels, Johannes T.; Speiser, Angelika; Steiert, Inge; Müller, Claudia A.; Klein, Gerd (2002-12-01). "E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation". Journal of Cell Science. 115 (23): 4505–4515. doi:10.1242/jcs.00142. ISSN 1477-9137.

[pmid17137867-14] Allakhverdi Z, Fitzpatrick D, Boisvert A, Baba N, Bouguermouh S, Sarfati M, Delespesse G (December 2006). "Expression of CD103 identifies human regulatory T-cell subsets". J. Allergy Clin. Immunol. 118 (6): 1342–9. doi:10.1016/j.jaci.2006.07.034. PMID 17137867.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

v t 단백질: 분화의 군집(인간 분화의 군집 목록 참조)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83년 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158(a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218(a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Search

ITGAE

네임스페이스

더

목차

조직 분포

함수

참고 항목

참조

추가 읽기

외부 링크