포유류 멸균 20-like kinase-1의 경우 STK4 를 참조한다. 간세포 성장인자 유사 단백질(HLP , HGFL 또는 HGFLP )로도 알려진 대식세포 자극 단백질(MSP )은 사람 에게서 MST1(대식세포 [5] [6] [7] 자극 1) 유전자에 의해 암호화되는 단백질 이다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000173531 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032591 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (Oct 1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel" . Am J Hum Genet . 43 (4): 442–51. PMC 1715492 PMID 2902784 . ^ Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ (Aug 1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3" . J Biol Chem . 268 (21): 15461–8. doi :10.1016/S0021-9258(18)82279-7 PMID 8393443 . ^ "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)" . 추가 정보 Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry . 30 (40): 9768–80. doi :10.1021/bi00104a029 . PMID 1655021 . Skeel A, Yoshimura T, Showalter SD, et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity" . J. Exp. Med . 173 (5): 1227–34. doi :10.1084/jem.173.5.1227 . PMC 2118857 PMID 1827141 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein" . J. Biol. Chem . 271 (15): 9024–32. doi :10.1074/jbc.271.15.9024 PMID 8621550 . Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain" . J. Biol. Chem . 271 (35): 21049–53. doi :10.1074/jbc.271.35.21049 PMID 8702870 . Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility" . J. Clin. Invest . 99 (4): 701–9. doi :10.1172/JCI119214 . PMC 507853 PMID 9045873 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Yoshikawa W, Hara H, Takehara T, et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein" . Arch. Biochem. Biophys . 363 (2): 356–60. doi :10.1006/abbi.1998.1090 . PMID 10068459 . Degen SJ, McDowell SA, Waltz SE, et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq . 8 (6): 409–13. doi :10.3109/10425179809020903 . PMID 10728827 . Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein" . J. Biol. Chem . 276 (24): 21932–7. doi :10.1074/jbc.M100652200 PMID 11274154 . Rampino T, Collesi C, Gregorini M, et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells" . J. Am. Soc. Nephrol . 13 (3): 649–57. doi :10.1681/ASN.V133649 PMID 11856768 . Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages" . J. Biol. Chem . 277 (41): 38104–10. doi :10.1074/jbc.M206167200 PMID 12177064 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration" . Dev. Cell . 5 (2): 257–71. doi :10.1016/S1534-5807(03)00201-6 PMID 12919677 . Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation" . J. Biol. Chem . 279 (5): 3726–32. doi :10.1074/jbc.M309342200 PMID 14597639 . Matsuzaki S, Canis M, Pouly JL, et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis" . Mol. Hum. Reprod . 11 (5): 345–9. doi :10.1093/molehr/gah162 PMID 15764806 . Zalcenstein A, Weisz L, Stambolsky P, et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53" . Oncogene . 25 (3): 359–69. doi :10.1038/sj.onc.1209061 PMID 16170349 . Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
앤지오포이에틴 CNTF EGF(ErbB)
Fgf.
FGFR1 FGFR2 어거니스트: 에르소페르민 FGF (1 , 2(bFGF), 3 , 4 , 5 , 6 , 7(KGF ), 8 , 9 , 10(KGF2), 17 , 18 , 22 Palifermin Repifermin Selpercatinib Sprifermin Trafermin FGFR3 FGFR4 정렬되어 있지 않다
HGF(c-Met) IGF
LNGF(p75NTR ) PDGF RET(GFL)
SCF(c-Kit) TGFβ 트랙
TrkA TrkB 어거니스트: 3,7-DHF 3, 7, 8, 2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7, 8, 2'-THF 7, 8, 3'-THF 아미트리푸틸린 BDNF BNN-20 디옥시제두닌 데프레닐 디오스메틴 DMAQ-B1 하이오크 LM22A-4 N-아세틸세로토닌 NT-3 NT-4 Norwogonin(5,7,8-THF) R7 R13 TDP6 TrkC
VEGF 다른이들 추가 성장 요인: 아드레날린 콜로니 자극 요인(대신 여기를 참조 ) 결합조직증식인자(CTGF) 에프린 (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )에리트로포이에틴 (대신 여기를 참조 )글루코오스-6-인산 이성질화효소(GPI, PGI, PHI, AMF) 글리아 성숙 계수(GMF) 간종유래증식인자(HDGF) 인터류킨 /T셀 성장인자 (대신 여기를 참조 )백혈병 억제인자(LIF) 대식세포자극단백질(MSP; HLP, HGFLP) 미드카인(NEGF2) 이행 자극 요인(MSF, PRG4) 온코모듈린 뇌하수체아데닐산시클라아제활성화펩타이드(PACAP) 플레이오트로핀 리네나아제 트롬보포이에틴 (대신 여기를 참조 )Wnt 시그널링 단백질 추가 성장인자 수용체 조절기: 세레브로신 (뉴로트로핀 혼합물)
케모카인 CSF
간섭체
IFNAR (α/β, I) 어거니스트: 알비테론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘 간섭 알파-n3 간섭 베타(IFN-β)( IFNB1 , IFNB3 )간섭 베타 1a 간섭 베타 1b Interferon kappa(IFN-'/'/'/'/'/', IFNK') 간섭 오메가(IFN-γ, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR(,, II) IFNLR(,, III) 여기서 IL-28R(IFNLR)을 참조해 주세요.
인터류킨 TGFβ TNF 다른이들
