CCL22

CCL22
식별자
별칭	CCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCY22, STCP-1, C-C 모티프 케모카인 리간드 22
외부 ID	OMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCard: CCL22
유전자 위치(인간)
쳇.	16번 염색체(인간)
끝	57,366,190 bp
RNA 표현 패턴
	표현된 상단
	맹장; ; 방광 점막; ; 림프절; ; 직장의; ; 인두의; ; 흉선; ; 추골결막; ; 외음부; ; 복부 피부; ; 사지의 피부;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	사이토카인 활동; CCR 케모킨 수용체 결합; 화학 작용;
셀룰러 컴포넌트	세포외 지역; 세포외 공간;
생물학적 과정	G 단백질 결합 수용체 신호 경로; 단모세포 화학적; 화학 매개 신호 경로; 세포 세포 신호; 종양 괴사 인자에 대한 세포 반응; 바이러스에 대한 대응; 중성미자 화학 약품; 화학적 축; GO:0032320, GO:00321, GO:0032855, GO:0043089, GTPase 활동에 대한 GO:0032854 양성 규제; 면역 반응; 인터루킨-1에 대한 세포 반응; ERK1 및 ERK2 계단식 규제; 인터페론 검출기에 대한 세포 반응; 세포 화학 작용; 림프구 화학적 축; 신호 전달; 염증 반응; 항균 펩타이드에 의해 매개되는 항균성 유머 면역 반응; 신호 수용체 활성 조절; 사이토카인 매개 신호 경로; 어시노필 화학약;
	출처:아미고 / 퀵고
직교체
	6367
	20299
	ENSG00000102962
	n/a
	O00626
	O88430
	NM_002990
	NM_009137
	NP_002981
	NP_033163
	위키다타
인간 보기/편집	마우스 보기/편집

C-C 모티브 케모킨 22는 인간에서 CCL22 유전자에 의해 암호화된 단백질이다.^[4]^[5]^[6]

이 유전자가 인코딩한 단백질은 덴드리트 세포와 대식세포에 의해 분비되며 CCR4와 같은 세포표면 케모킨 수용체와 상호작용하여 목표 세포에 미치는 영향을 이끌어낸다.^[7]CCL22의 유전자는 CX3CL1과 CCL17이라고 불리는 다른 화학물질이 군집화된 인간 16번 염색체에 위치한다.^[8]^[9]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000102962 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997). "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells". J Exp Med. 185 (9): 1595–604. doi:10.1084/jem.185.9.1595. PMC 2196293. PMID 9151897.
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.
^ "Entrez Gene: CCL22 chemokine (C-C motif) ligand 22".
^ Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286.
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

추가 읽기

Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells". J. Leukoc. Biol. 71 (2): 173–83. PMID 11818437.
Gear AR, Camerini D (2003). "Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense". Microcirculation. 10 (3–4): 335–50. doi:10.1038/sj.mn.7800198. PMID 12851650. S2CID 10791409.
Chang M, McNinch J, Elias C, et al. (1997). "Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes". J. Biol. Chem. 272 (40): 25229–37. doi:10.1074/jbc.272.40.25229. PMID 9312138.
Pal R, Garzino-Demo A, Markham PD, et al. (1997). "Inhibition of HIV-1 infection by the beta-chemokine MDC". Science. 278 (5338): 695–8. doi:10.1126/science.278.5338.695. PMID 9381181.
Imai T, Chantry D, Raport CJ, et al. (1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
Struyf S, Proost P, Sozzani S, et al. (1998). "Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor". J. Immunol. 161 (6): 2672–5. PMID 9743322.
Meucci O, Fatatis A, Simen AA, et al. (1998). "Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14500–5. doi:10.1073/pnas.95.24.14500. PMC 24402. PMID 9826729.
Proost P, Struyf S, Schols D, et al. (1999). "Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction". J. Biol. Chem. 274 (7): 3988–93. doi:10.1074/jbc.274.7.3988. PMID 9933589.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Annunziato F, Romagnani P, Cosmi L, et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection". J. Immunol. 165 (1): 238–46. doi:10.4049/jimmunol.165.1.238. PMID 10861057.
Vulcano M, Albanesi C, Stoppacciaro A, et al. (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286.
Berin MC, Dwinell MB, Eckmann L, Kagnoff MF (2001). "Production of MDC/CCL22 by human intestinal epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (6): G1217–26. doi:10.1152/ajpgi.2001.280.6.G1217. PMID 11352815.
Lambeir AM, Proost P, Durinx C, et al. (2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family". J. Biol. Chem. 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394.
Wakahara S, Fujii Y, Nakao T, et al. (2002). "Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood". Cytokine. 16 (4): 143–52. doi:10.1006/cyto.2001.0958. PMID 11792124.
Ghia P, Strola G, Granziero L, et al. (2002). "Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22". Eur. J. Immunol. 32 (5): 1403–13. doi:10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y. PMID 11981828.
D'Ambrosio D, Albanesi C, Lang R, et al. (2002). "Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion". J. Immunol. 169 (5): 2303–12. doi:10.4049/jimmunol.169.5.2303. PMID 12193695.
Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003). "Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans". Int. Immunol. 14 (11): 1255–62. doi:10.1093/intimm/dxf098. PMID 12407016.

외부 링크

UCSC 게놈 브라우저의 인간 CCL22 유전체 위치 및 CCL22 유전자 세부 정보 페이지.

16번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000102962 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9151897-4] Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997). "Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells". J Exp Med. 185 (9): 1595–604. doi:10.1084/jem.185.9.1595. PMC 2196293. PMID 9151897.

[pmid9691168-5] Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.

[entrez-6] "Entrez Gene: CCL22 chemokine (C-C motif) ligand 22".

[pmid11241286-7] Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). "Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo". Eur. J. Immunol. 31 (3): 812–22. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L. PMID 11241286.

[autogenerated1-8] Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168. S2CID 46851784.

[pmid10493829-9] Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

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CCL22

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