PDGFA
PDGFA
혈소판 유래 성장인자 서브유닛 A는 인간에서 PDGFA [5][6]유전자에 의해 코드되는 단백질이다.
이 유전자에 의해 코드된 단백질은 혈소판 유래 성장인자 패밀리의 구성원이다.이 패밀리의 4개 구성원은 중간엽 기원의 세포에 대한 승모판 유발 인자로 8개의 시스테인을 모티브로 하는 것이 특징이다.이 유전자 생성물은 혈소판 유래 성장인자 베타 폴리펩타이드를 가진 호모디머 또는 헤테로디머로 존재할 수 있으며, 여기서 이합체는 디술피드 결합으로 연결됩니다.녹아웃 마우스를 사용한 연구는 고환의 올리고덴드로사이트, 폐포 평활근 세포, 레이디지 세포에 세포 결함이 있다는 것을 보여주었다. 녹아웃 마우스는 배아로서 또는 출생 직후에 죽는다.이 [7]유전자에 대해 두 가지 스플라이스 변형이 확인되었다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000197461 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025856 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Stenman G, Rorsman F, Huebner K, Betsholtz C (Sep 1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet. 60 (3–4): 206–7. doi:10.1159/000133337. PMID 1505216.
- ^ Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S (Mar 1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science. 243 (4892): 800–4. doi:10.1126/science.2536956. PMID 2536956.
- ^ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide".
추가 정보
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