혈소판유래증식인자 D는 인간 에서 PDGFD 유전자에 [5] [6] [7] 단백질 이다.
이 유전자에 의해 코드된 단백질은 혈소판 유래 성장인자 패밀리의 구성원이다. 이 패밀리의 4개 구성원은 중간엽 기원의 세포에 대한 승모판 유발 인자로 8개의 시스테인의 핵심 모티브가 특징이며, 그 중 7개는 이 인자에서 발견된다. 이 유전자 생성물은 호모디머 를 형성할 뿐이므로 다른 세 가족과는 이량화되지 않는다. 이 패밀리의 알파 및 베타 구성원과는 달리 특이한 N 터미널 도메인 인 CUB 도메인 이 있습니다. 이 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000170962 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032006 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun . 280 (3): 733–7. doi :10.1006/bbrc.2000.4187 . PMID 11162582 . ^ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res . 62 (9): 2468–73. PMID 11980634 . ^ a b "Entrez Gene: PDGFD platelet derived growth factor D" . 추가 정보 Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol . 3 (5): 512–6. doi :10.1038/35074588 . PMID 11331881 . S2CID 25074372 . LaRochelle WJ, Jeffers M, McDonald WF, et al. (2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol . 3 (5): 517–21. doi :10.1038/35074593 . PMID 11331882 . S2CID 19633551 . Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes" . Circulation . 103 (18): 2242–7. doi :10.1161/01.cir.103.18.2242 PMID 11342471 . Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis . 8 : 185–95. PMID 12107412 . Changsirikulchai S, Hudkins KL, Goodpaster TA, et al. (2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys" . Kidney Int . 62 (6): 2043–54. doi :10.1046/j.1523-1755.2002.00662.x PMID 12427128 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Taneda S, Hudkins KL, Topouzis S, et al. (2004). "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury" . J. Am. Soc. Nephrol . 14 (10): 2544–55. doi :10.1097/01.ASN.0000089828.73014.C8 PMID 14514732 . Uutela M, Wirzenius M, Paavonen K, et al. (2004). "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis" . Blood . 104 (10): 3198–204. doi :10.1182/blood-2004-04-1485 PMID 15271796 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ray S, Gao C, Wyatt K, et al. (2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation" . J. Biol. Chem . 280 (9): 8494–502. doi :10.1074/jbc.M413570200 PMID 15611105 . Ustach CV, Kim HR (2005). "Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells" . Mol. Cell. Biol . 25 (14): 6279–88. doi :10.1128/MCB.25.14.6279-6288.2005 . PMC 1168822 PMID 15988036 . Liu MY, Eyries M, Zhang C, et al. (2006). "Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1" . Blood . 107 (6): 2322–9. doi :10.1182/blood-2005-06-2377 PMID 16189269 .
앤지오포이에틴 CNTF EGF(ErbB)
Fgf.
FGFR1 FGFR2 어거니스트: 에르소페르민 FGF (1 , 2(bFGF), 3 , 4 , 5 , 6 , 7(KGF ), 8 , 9 , 10(KGF2), 17 , 18 , 22 팔리퍼민 레피퍼민 셀퍼카티니브 스프리퍼민 트라페르민 FGFR3 FGFR4 정렬되어 있지 않다
HGF(c-Met) IGF
LNGF(p75NTR ) PDGF RET(GFL)
SCF(c-Kit) TGFβ 트랙
TrkA TrkB 어거니스트: 3,7-DHF 3, 7, 8, 2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7, 8, 2'-THF 7, 8, 3'-THF 아미트리푸틸린 BDNF BNN-20 디옥시제두닌 데프레닐 디오스메틴 DMAQ-B1 하이오크 LM22A-4 N-아세틸세로토닌 NT-3 NT-4 Norwogonin(5,7,8-THF) R7 R13 TDP6 TrkC
VEGF 다른이들 추가 성장 요인: 아드레날린 콜로니 자극 요인(대신 여기를 참조 ) 결합조직증식인자(CTGF) 에프린 (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )에리트로포이에틴 (대신 여기를 참조 )글루코오스-6-인산 이성질화효소(GPI, PGI, PHI, AMF) 글리아 성숙 계수(GMF) 간종유래증식인자(HDGF) 인터류킨 /T셀 성장인자 (대신 여기를 참조 )백혈병 억제인자(LIF) 대식세포자극단백질(MSP; HLP, HGFLP) 미드카인(NEGF2) 이행 자극 요인(MSF, PRG4) 온코모듈린 뇌하수체아데닐산시클라아제활성화펩타이드(PACAP) 플레이오트로핀 리네나아제 트롬보포이에틴 (대신 여기를 참조 )Wnt 시그널링 단백질 추가 성장인자 수용체 조절기: 세레브로신 (뉴로트로핀 혼합물)
