혈관내피증식인자 B

VEGFB
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2C7W, 2VWE, 2XAC
식별자
에일리어스	VEGFB, VEGFL, VRF, 혈관내피증식인자 B
외부 ID	OMIM : 601398 MGI : 106199 HomoloGene : 87131 GenCard : VEGFB
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	64,239,264 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	6,965,019 bp
RNA발현패턴
	상단 표시 위치:
	우관상 동맥; ; 좌관상동맥; ; 슬와 동맥; ; 상행 대동맥; ; 뇌하수체 전엽; ; 자궁경관; ; 갑상선 우엽; ; 갑상선 좌엽; ; 좌측 자궁관; ; 췌장체;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	헤파린 결합; 단백질 호모다이머화; GO:0001948, GO:0016582 단백질 결합; 단백질 헤테로다이머화 활성; 화학 유인제 활성; 성장인자 활성; 혈관내피증식인자수용체1결합; 혈관내피증식인자수용체2결합; 혈관내피증식인자수용체3결합; 혈관내피증식인자수용체결합;
셀룰러 컴포넌트	막; 세포내 해부학적 구조; 세포외 영역; 혈소판 알파 과립 루멘; 세포외 공간;
생물학적 과정	GO: 1904089 뉴런 아포토시스 과정의 음성 조절; 혈관내피성장인자수용체신호경로양성조절; 단백질인산화효소B신호전달양성조절; 심근 수축; 단백질 O결합 배당체화; 혈소판 탈과민; 아포토시스 과정의 음성 조절; 관상 동맥 혈관의 발달; 유전자 발현 음성 조절; 심장 발달; 혈관 투과성의 양성 조절; 혈관창상치유의 양성조절; ERK1 및 ERK2 캐스케이드 양의 조절; 펩티딜티로신인산화양성조절; 세포 분열의 양성 조절; 양성 주화성; 저산소증에 대한 반응; 혈관 형성; 내피세포 증식의 양성 조절; 혈관신생의 양성 조절; 혈관내피증식인자수용체신호경로; 양화성 유도; 비만세포주화성양조절; 신호수용체활성조절; 단백질인산화양조절; 발아 혈관 형성; 혈관내피증식인자신호경로;
	출처:아미고 / QuickGO
맞춤법
	7423
	22340
	ENSG00000173511
	ENSMUSG000024962
	P49765
	P49766
	NM_003377; NM_001243733
	NM_001185164; NM_011697
	NP_001230662; NP_003368
	NP_001172093; NP_035827
	위키데이터
인간 보기/편집	마우스 표시/편집

혈관내피증식인자 B는 VEGF-B ^[5]유전자에 의해 인간에서 부호화되는 단백질이다.VEGF-B는 혈관내피성장인자군에 속하는 성장인자로 VEGF-A가 가장 잘 알려져 있다.

기능.

VEGF-A와 달리 VEGF-B는 혈관 시스템에서 덜 뚜렷한 역할을 합니다.VEGF-A는 혈관의 형성에 중요한 반면, VEGF-B는 병리학적 조건 ^[6]중 새로 형성된 혈관의 유지에만 관여하는 것으로 보인다.VEGF-B는 또한 여러 종류의 뉴런에서 중요한 역할을 한다.뇌졸중 중에는^[8] 망막과^[7] 대뇌피질의 뉴런을 보호하고 근위축성 ^[9]측삭경화증과 같은 운동뉴런 질환 중에는 운동뉴런을 보호하는 데 중요하다.

VEGF-B는 FLT1 ^[10]수용체를 통해 그 효과를 발휘한다.

VEGF-B는 또한 심장과 ^[11]^[12]골격근에서 지방산의 내피 흡수 및 운반을 조절하는 것으로 밝혀졌다.

상호 작용

혈관내피성장인자 B는 FLT1과 ^[13]^[14]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000173511 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024962 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: VEGFB vascular endothelial growth factor B".
^ Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X (April 2009). "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6152–7. doi:10.1073/pnas.0813061106. PMC 2669337. PMID 19369214.
^ Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X (March 2008). "VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats". J. Clin. Invest. 118 (3): 913–23. doi:10.1172/JCI33673. PMC 2230661. PMID 18259607.
^ Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA (October 2004). "Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice". J. Cereb. Blood Flow Metab. 24 (10): 1146–52. doi:10.1097/01.wcb.0000134477.38980.38. PMID 15529014.
^ Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (October 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMC 6671326. PMID 18923022.
^ Yamazaki Y, Morita T (November 2006). "Molecular and functional diversity of vascular endothelial growth factors". Mol. Divers. 10 (4): 515–27. doi:10.1007/s11030-006-9027-3. PMID 16972015. S2CID 28692204.
^ Muoio DM (July 2010). "Metabolism and vascular fatty acid transport". N. Engl. J. Med. 363 (3): 291–3. doi:10.1056/NEJMcibr1005397. PMID 20647206.
^ Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U (October 2012). "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes". Nature. 490 (7420): 426–30. doi:10.1038/nature11464. PMID 23023133. S2CID 4315297.
^ Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (September 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.
^ Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

추가 정보

Poesen K, Lambrechts D, et al. (2008). "Novel Role for Vascular Endothelial Growth Factor (VEGF)Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMC 6671326. PMID 18923022.
Joukov V, Kaipainen A, Jeltsch M, et al. (1997). "Vascular endothelial growth factors VEGF-B and VEGF-C". J. Cell. Physiol. 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
Olofsson B, Pajusola K, Kaipainen A, et al. (1996). "Vascular endothelial growth factor B, a novel growth factor for endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2576–81. doi:10.1073/pnas.93.6.2576. PMC 39839. PMID 8637916.
Olofsson B, Pajusola K, von Euler G, et al. (1996). "Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform". J. Biol. Chem. 271 (32): 19310–7. doi:10.1074/jbc.271.32.19310. PMID 8702615.
Grimmond S, Lagercrantz J, Drinkwater C, et al. (1996). "Cloning and characterization of a novel human gene related to vascular endothelial growth factor". Genome Res. 6 (2): 124–31. doi:10.1101/gr.6.2.124. PMID 8919691.
Olofsson B, Korpelainen E, Pepper MS, et al. (1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.
Makinen T, Olofsson B, Karpanen T, et al. (1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.
Ikuta T, Ariga H, Matsumoto K (2001). "Extracellular matrix tenascin-X in combination with vascular endothelial growth factor B enhances endothelial cell proliferation". Genes Cells. 5 (11): 913–927. doi:10.1046/j.1365-2443.2000.00376.x. PMID 11122379. S2CID 41366972.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Qi JH, Ebrahem Q, Moore N, et al. (2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat. Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295. S2CID 12563403.
Trompezinski S, Berthier-Vergnes O, Denis A, et al. (2004). "Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts". Exp. Dermatol. 13 (2): 98–105. doi:10.1111/j.0906-6705.2004.00137.x. PMID 15009103. S2CID 13040175.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Timoshenko AV, Chakraborty C, Wagner GF, Lala PK (2006). "COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer". Br. J. Cancer. 94 (8): 1154–63. doi:10.1038/sj.bjc.6603067. PMC 2361247. PMID 16570043.
Iyer S, Scotney PD, Nash AD, Ravi Acharya K (2006). "Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding". J. Mol. Biol. 359 (1): 76–85. doi:10.1016/j.jmb.2006.03.002. PMID 16616187.
Yamada E, Yamazaki K, Takano K, et al. (2007). "Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors". Thyroid. 16 (6): 545–54. doi:10.1089/thy.2006.16.545. PMID 16839256.
de Paulis A, Prevete N, Fiorentino I, et al. (2007). "Expression and functions of the vascular endothelial growth factors and their receptors in human basophils". J. Immunol. 177 (10): 7322–31. doi:10.4049/jimmunol.177.10.7322. PMID 17082651.

외부 링크

PDBe-KB는 인간 혈관 내피 성장 인자 B에 대한 PDB에서 사용 가능한 모든 구조 정보에 대한 개요를 제공합니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000173511 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000024962 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VEGFB vascular endothelial growth factor B".

[pmid19369214-6] Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X (April 2009). "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6152–7. doi:10.1073/pnas.0813061106. PMC 2669337. PMID 19369214.

[pmid18259607-7] Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X (March 2008). "VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats". J. Clin. Invest. 118 (3): 913–23. doi:10.1172/JCI33673. PMC 2230661. PMID 18259607.

[pmid15529014-8] Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA (October 2004). "Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice". J. Cereb. Blood Flow Metab. 24 (10): 1146–52. doi:10.1097/01.wcb.0000134477.38980.38. PMID 15529014.

[pmid18923022-9] Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (October 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMC 6671326. PMID 18923022.

[pmid16972015-10] Yamazaki Y, Morita T (November 2006). "Molecular and functional diversity of vascular endothelial growth factors". Mol. Divers. 10 (4): 515–27. doi:10.1007/s11030-006-9027-3. PMID 16972015. S2CID 28692204.

[pmid20647206-11] Muoio DM (July 2010). "Metabolism and vascular fatty acid transport". N. Engl. J. Med. 363 (3): 291–3. doi:10.1056/NEJMcibr1005397. PMID 20647206.

[pmid23023133-12] Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U (October 2012). "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes". Nature. 490 (7420): 426–30. doi:10.1038/nature11464. PMID 23023133. S2CID 4315297.

[pmid9751730-13] Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (September 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.

[pmid10409677-14] Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (July 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

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혈관내피증식인자 B

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크