CXCL11

CXCL11
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1 RJT
식별자
에일리어스	CXCL11, H174, I-TAC, IP-9, IP9, SKYB11, SKYB9B, b-R1, C-X-C 모티브 케모카인 배위자 11
외부 ID	OMIM: 604852 HomoloGene: 3944 GeneCard: CXCL11
유전자 위치(인간)
크르.	4번 염색체(인간)
끝.	76,041,415 bp
RNA발현패턴
	상단 표시 위치:
	부록; ; 췌장체; ; 림프절; ; 직장; ; 평활근 조직; ; 랑게르한스 섬; ; 단구; ; 아킬레스건; ; 안검결막; ; 비장;
	없음
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	케모카인 활성; 사이토카인 활성; 헤파린 결합; 단백질 결합; CXCR3케모카인수용체결합;
셀룰러 컴포넌트	세포외 영역; 세포외 공간; 세포내 해부학적 구조;
생물학적 과정	주화성; 백혈구 주화성 양성 조절; T세포주화성; 케모카인결합신호경로; 리포다당류에 대한 반응; 세포신호; 세포에 격리된 칼슘 이온 방출의 양성 조절; cAMP 매개 시그널링의 양성 조절; 세포군 증식 조절; 면역 반응; 신호 변환; 방위 응답; 염증 반응; 항균펩타이드에 의해 매개되는 항균성 체액 면역 반응; 신호수용체활성조절; G단백질결합수용체신호경로; 아데닐산시클라아제활성화G단백질결합수용체신호경로; 호중구 주화성; 백혈구 주화성; 리포다당류에 대한 세포반응;
	출처:아미고 / QuickGO
맞춤법
	6373
	없음
	ENSG00000169248
	없음
	O14625
	없음
	NM_005409; NM_001302123
	없음
	NP_001289052; NP_005400
	없음
	위키데이터
인간 보기/편집

C-X-C 모티브 케모카인 11(CXCL11)은 CXCL11 ^[3]유전자에 의해 인체 내에서 부호화되는 단백질이다.

C-X-C 모티브 케모카인 11은 CXC 케모카인족에 속하는 소형 사이토카인으로, Interferon-gamma-inclube protein 9(IP-9)라고도 불린다.말초혈액 백혈구, 췌장, 간에서 많이 발현되며 흉선, 비장, 폐에서 중간 수준, 소장, 태반, ^[4]전립선에서 발현 수준이 낮았다.

CXCL11의 유전자 발현은 IFN-γ 및 IFN-β에 의해 강하게 유도되며 IFN-α에 ^[5]의해 약하게 유도된다.이 케모카인은 세포 표면 케모카인 수용체 CXCR3와 상호작용하여 표적 세포에 미치는 영향을 유도하며, 이 수용체에 대한 다른 리간드인 CXCL9 및 ^[4]^[6]CXCL10보다 높은 친화력을 가지고 있다.그것의 유전자는 CXC 케모카인 ^[7]^[8]계열의 많은 다른 구성원들과 함께 인간 염색체 4에 위치해 있다.

바이오마커

CXCL9, -10, -11은 심부전 및 좌심실 기능 장애의 발달에 유효한 바이오마커로 입증되었으며, 이는 이러한 화학 물질의 수치와 부정적인 ^[9]^[10]심장 리모델링의 발달 사이에 병태 생리학적 관계가 있음을 시사한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000169248 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11".
^ ^a ^b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (June 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine. 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760.
^ Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (September 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry. 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467.
^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762.
^ Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics. 81 (3–4): 271–2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304.
^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
^ Altara R, Gu YM, Struijker-Boudier HA, Thijs L, Staessen JA, Blankesteijn WM (2015). "Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study". PLOS ONE. 10 (10): e0141394. Bibcode:2015PLoSO..1041394A. doi:10.1371/journal.pone.0141394. PMC 4624781. PMID 26506526.
^ Altara R, Manca M, Hessel MH, Gu Y, van Vark LC, Akkerhuis KM, Staessen JA, Struijker-Boudier HA, Booz GW, Blankesteijn WM (August 2016). "CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study" (PDF). Journal of Cardiovascular Translational Research. 9 (4): 302–14. doi:10.1007/s12265-016-9703-3. PMID 27271043. S2CID 41188765.

외부 링크

UCSC 게놈 브라우저의 인간 CXCL11 게놈 위치 및 CXCL11 유전자 상세 페이지.

추가 정보

Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (September 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry. 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467.
Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V, Stover J, Williamson MJ, McCoy JM (October 1997). "A genetic selection for isolating cDNAs encoding secreted proteins". Gene. 198 (1–2): 289–96. doi:10.1016/S0378-1119(97)00330-2. PMID 9370294.
Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (June 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine. 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760.
Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics. 81 (3–4): 271–2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304.
Luo Y, Kim R, Gabuzda D, Mi S, Collins-Racie LA, Lu Z, Jacobs KA, Dorf ME (December 1998). "The CXC-chemokine, H174: expression in the central nervous system". Journal of Neurovirology. 4 (6): 575–85. doi:10.3109/13550289809114224. PMID 10065899.
Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762.
Laich A, Meyer M, Werner ER, Werner-Felmayer G (May 1999). "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)". Journal of Interferon & Cytokine Research. 19 (5): 505–13. doi:10.1089/107999099313956. PMID 10386863.
Tensen CP, Flier J, Rampersad SS, Sampat-Sardjoepersad S, Scheper RJ, Boorsma DM, Willemze R (July 1999). "Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 167–72. doi:10.1016/s0167-4781(99)00084-6. PMID 10395932.
Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I (February 2001). "The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3". The Journal of Biological Chemistry. 276 (5): 2986–91. doi:10.1074/jbc.M005652200. PMID 11110785.
Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpé S, Van Damme J, De Meester I (August 2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family". The Journal of Biological Chemistry. 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394.
Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, van der Schors RC, Werner-Felmayer G, Boorsma DM, Scheper RJ, Willemze R, Tensen CP (September 2001). "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity". European Journal of Biochemistry. 268 (18): 4992–9. doi:10.1046/j.0014-2956.2001.02433.x. PMID 11559369.
Mohan K, Ding Z, Hanly J, Issekutz TB (June 2002). "IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha". Journal of Immunology. 168 (12): 6420–8. doi:10.4049/jimmunol.168.12.6420. PMID 12055261.
Basu S, Schaefer TM, Ghosh M, Fuller CL, Reinhart TA (May 2002). "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines". Cytokine. 18 (3): 140–8. doi:10.1006/cyto.2002.0875. PMID 12126650.
Salmaggi A, Gelati M, Dufour A, Corsini E, Pagano S, Baccalini R, Ferrero E, Scabini S, Silei V, Ciusani E, De Rossi M (June 2002). "Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis". Journal of Interferon & Cytokine Research. 22 (6): 631–40. doi:10.1089/10799900260100114. PMID 12162873.
Rani MR, Hibbert L, Sizemore N, Stark GR, Ransohoff RM (October 2002). "Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene". The Journal of Biological Chemistry. 277 (41): 38456–61. doi:10.1074/jbc.M203204200. PMID 12169689.
Kao J, Kobashigawa J, Fishbein MC, MacLellan WR, Burdick MD, Belperio JA, Strieter RM (April 2003). "Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease". Circulation. 107 (15): 1958–61. doi:10.1161/01.CIR.0000069270.16498.75. PMID 12695288.
Satish L, Yager D, Wells A (June 2003). "Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair". The Journal of Investigative Dermatology. 120 (6): 1110–7. doi:10.1046/j.1523-1747.2003.12230.x. PMID 12787142.
Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K, Akdis CA (July 2003). "A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis". Journal of Immunology. 171 (2): 1078–84. doi:10.4049/jimmunol.171.2.1078. PMID 12847282.
Xanthou G, Duchesnes CE, Williams TJ, Pease JE (August 2003). "CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11". European Journal of Immunology. 33 (8): 2241–50. doi:10.1002/eji.200323787. PMID 12884299. S2CID 24555816.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000169248 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11".

[pmid9625760-4] Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (June 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine. 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760.

[pmid8798467-5] Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (September 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry. 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467.

[pmid10233762-6] Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762.

[pmid9730616-7] Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics. 81 (3–4): 271–2. doi:10.1159/000015043. PMID 9730616. S2CID 46846304.

[pmid10343098-8] O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

[9] Altara R, Gu YM, Struijker-Boudier HA, Thijs L, Staessen JA, Blankesteijn WM (2015). "Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study". PLOS ONE. 10 (10): e0141394. Bibcode:2015PLoSO..1041394A. doi:10.1371/journal.pone.0141394. PMC 4624781. PMID 26506526.

[10] Altara R, Manca M, Hessel MH, Gu Y, van Vark LC, Akkerhuis KM, Staessen JA, Struijker-Boudier HA, Booz GW, Blankesteijn WM (August 2016). "CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study" (PDF). Journal of Cardiovascular Translational Research. 9 (4): 302–14. doi:10.1007/s12265-016-9703-3. PMID 27271043. S2CID 41188765.

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CXCL11

네임스페이스

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목차

바이오마커

레퍼런스

외부 링크

추가 정보