사이클린 의존키나제4
Cyclin-dependent kinase 4
세포분열단백질키나아제4로도 알려진 사이클린 의존성 키나제4는 인간에서 CDK4 유전자에 의해 암호화된 효소다.CDK4는 사이클린 의존 키나제 계열의 일원이다.
함수
이 유전자가 인코딩한 단백질은 Ser/Tr 단백질 키나아제 계열의 일원이다.이 단백질은 S. 세레비시아 cdc28과 S. 퐁베 cdc2의 유전자 생성물과 매우 유사하다.그것은 세포 주기 G1 위상 진행에 중요한 단백질 키나아제 복합체의 촉매 소단위다.이 키나제의 활성은 규제 서브유닛 D형 사이클린과 CDK 억제제 p16에INK4a 의해 제어되는 G1-S 단계로 제한된다.이 키나아제는 레티노블레스토마 유전자 제품(Rb)의 인산화 작용에 책임이 있는 것으로 나타났다.[4]사이클린 D-CDK4(DC) 복합체의 Ser/Thr-Kinase 성분으로, RB1을 포함한 레티노블레스모종(RB) 단백질 계열의 부재를 인산화 및 억제하고 G1/S 전환 시 셀 사이클을 조절한다.RB1의 인산화 작용은 전사인자 E2F를 RB/E2F 복합체로부터 분리시키고, G1 단계를 통한 진행을 담당하는 E2F 표적 유전자의 후속 전사를 가능하게 한다.G1 초기 단계에서 저인산염 RB1.사이클린 D-CDK4 단지는 다양한 미생물과 항미생성 신호의 주요 통합업체다.또한 SMAD3를 세포 주기 의존적인 방식으로 인지하고 전사 활동을 억제한다.사이클린 D-CDK4 복합체의 핵 변환 및 활동에 필요한 3차 복합체 구성품, 사이클린 D/CDK4/CDK1B.[5]
임상적 유의성
D형 사이클린, p16(INK4a), CDKN2A, Rb를 포함한 관련 단백질뿐만 아니라 이 유전자의 돌연변이는 모두 다양한 암의 종양기세증과 관련이 있는 것으로 밝혀졌다.CDK4(R24C)의 특정 지점 돌연변이는 흑색종 환자에서 처음 확인되었다.이 돌연변이는 동물 모델에도 도입되었고 암 운전자 종양 유전자로서의 역할도 철저히 연구되었다.오늘날에는 규제완화 CDK4가 일부 암유형에서는 잠재적 치료목표로 여겨지고 있으며 다양한 CDK4 억제제가 임상시험에서 암치료에 대해 시험되고 있다.[6][7]
이 유전자의 다중 폴리아데닐화 부위가 보고되었다.[4]
그것은 사이클린 D에 의해 규제된다.
억제제
리보시리브는 미국 FDA가 승인한 에스트로겐 수용체 양성/HER2 음성급 유방암 치료를 위한 CDK4 및 CDK6 억제제다.[8]
다양한 CDK의 억제제는 CDK 억제제를 참조하십시오.
상호작용
Cyclin 의존성 키나제 4가 다음과 상호작용하는 것으로 나타났다.
사멸과 관련된 신호 전달 경로 개요.((핑크) 핵에 있는 CDK4)
참조
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추가 읽기
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외부 링크
- Cyclin-dependent+Kinase+4(미국 국립 의학 라이브러리 의료 과목 제목)
- UCSC 게놈 브라우저에서 CDK4 인간 유전자 위치.
- UCSC 게놈 브라우저의 CDK4 인간 유전자 세부 정보.
