호모 사피엔스 종의 단백질 코드 유전자
Hsp90 공동 보호자 Cdc37 은 CDC37 [5] [6] 단백질 이다.
이 유전자에 의해 암호화된 단백질은 사카로미세스 세레비시아 의 세포 분열 주기 조절 단백질인 Cdc 37과 매우 유사하다. 이 단백질은 세포 신호 전달에서 특정한 기능을 가진 분자 샤페론 이다. Hsp90 및 CDK4, CDK6 , SRC , RAF1 , MOK 및 eIF-2 알파 키나아제 등 다양 한 단백질 키나제들과 복합체를 형성하는 것으로 나타났다.Hsp90을 표적 [7]
상호 작용 CDC37은 다음 제품과 상호작용하는 것 으로 나타났습니다.
도메인 아키텍처 CDC37은 3개의 구조 도메인으로 구성됩니다. N 말단 도메인은 단백질 [15] 결합 합니다.중심 도메인은 Hsp90 샤페론 (히트 쇼크 단백질 90) 결합 [16] C 터미널 도메인의 기능이 불분명합니다.
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