사이클린 E1

CCNE1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1W98
식별자
별칭	CCNE1, CCNE, pcyclin E1
외부 ID	OMIM: 123837 MGI: 88316 HomoloGene: 14452 GeneCard: CCNE1
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	29,824,312 bp
유전자 위치(마우스)
쳇.	7번 염색체(쥐)
끝	37,806,959 bp
RNA 표현 패턴
	표현된 상단
	2차 난모세포; ; 태반의; ; 골수; ; 양수; ; 폐골.; ; 자궁내막 세포; ; 골수 세포; ; 소뇌반구; ; 직장의; ; 태아;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0001105 전사 공동활성화기 활동; 키나제 활동; 사이클린 유도 단백질 세린/트레오닌 키나아제 조절기 활동; GO:0001948 단백질 결합; 안드로겐 수용체 결합; 단백질 키나아제 결합; 사이클린 유도 단백질 세린/트레오닌 키나아제 활성; 단백질 키나아제 활성;
셀룰러 컴포넌트	시토솔; 사이클린-배열 단백질 키나아제 홀로엔자임 복합체; 핵종의; 핵의; 사이클린 E1-CDK2 복합체; 세포질; 센트로놈의;
생물학적 과정	안드로겐 수용체 신호 경로; Wnt 신호 경로; 유사 세포 주기의 G1/S 전환과 관련된 전사 규정; 세포 주기 조절; 세포 분열; 전사의 양성적 조절, DNA-템플링; 단백질 인산화; DNA 복제 시작; 세포 순환; 단백질 키나아제 활성 조절; RNA 중합효소 II에 의한 전사의 음성 조절; 말단소립 정비; 감수분열에서 동질 염색체 결합; 감수 세포 순환에 관여하는 염색체 조직; 유사 세포 주기의 G1/S 전환; 싸이클린-기타 단백질 세린/트레오닌 키나아제 활성 조절; GO:0007067 유사 세포 주기; 핵분열 규제; 세포 인구 증식에 대한 긍정적인 규제; 세포 주기의 양성 조절; 유사 세포 주기의 G1/S 전이 양성 규제; GO:0007090 유사 세포 주기 위상 전환;
	출처:아미고 / 퀵고
직교체
	898
	12447
	ENSG00000105173
	ENSMUSG00000002068
	P24864
	Q61457년
	NM_001238; NM_057182; NM_001322259; NM_001322261; NM_001322262
	NM_007633
NP_001229; NP_001309188; NP_001309190; NP_001309191; NP_001309188.1;
	NP_001309190.1
	NP_031659
	위키다타
인간 보기/편집	마우스 보기/편집

G1/S 특유의 사이클린-E1은 인간에서 CCNE1 유전자에 의해 암호화된 단백질이다.^[5]

함수

이 유전자에 의해 암호화된 단백질은 보존도가 높은 사이클린 계열에 속하는데, 그 구성원은 세포 순환을 통해 단백질의 풍부함을 극적으로 주기적인 것으로 특징지어진다.사이클린은 CDK의 조절기로서 기능한다. 다른 사이클린들은 각각의 유사성 사건의 시간적 조정에 기여하는 뚜렷한 표현과 분해 패턴을 보인다.이 사이클린은 CDK2의 규제 하위단위로 기능하며, 셀 사이클 G1/S 전환에 필요한 활동이다.이 단백질은 G1-S상 경계에서 축적되며 세포가 S상을 통해 진행되면서 분해된다.이 유전자의 과도한 압착은 많은 종양에서 관찰되어 염색체가 불안정해지고, 따라서 종양에 기여할 수 있다.이 단백질은 세포주기 조절 히스톤 유전자 발현에 참여하고 pRB가 없을 때 세포주기 진행을 촉진하는 데 중요한 역할을 하는 NPAT 단백질(ATM locus에 매핑된 핵단백질)의 인산화 작용과 연관되고 관여하는 것으로 밝혀졌다.구별되는 등소형을 인코딩하는 이 유전자의 두 가지 다른 분할된 대본 변형이 설명되었다.2개의 추가 스플라이스 변형이 보고되었지만 상세한 뉴클레오티드 시퀀스 정보는 아직 이용할 수 없다.^[6]

상호작용

Cyclin E1은 다음과 상호작용하는 것으로 나타났다.

CDC25A,^[7]^[8]
CDKN1B,^[7]^[9]
CULL3^[10]
Cdk1,^[7]^[11]
사이클린 의존성 ^[7]^[9]^[11]^[12]^[13]^[14]키나제 2,
HERC5,^[15]
P21,^[12]
레티노블레스모세포종 같은 단백질 2, ^[7]^[16]그리고
SMARCA4.^[7]^[17]

참고 항목

사이클린 E

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000105173 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000002068 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
^ "Entrez Gene: CCNE1 cyclin E1".
^ ^a ^b ^c ^d ^e ^f Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
^ Xu X, Burke SP (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.
^ ^a ^b Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell. 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. PMC 140238. PMID 12529437.
^ Singer JD, Gurian-West M, Clurman B, Roberts JM (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.
^ ^a ^b Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. doi:10.1126/science.1388288. PMID 1388288.
^ ^a ^b McKenzie PP, Danks MK, Kriwacki RW, Harris LC (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. 63 (13): 3840–4. PMID 12839982.
^ Mayer C, Zhao J, Yuan X, Grummt I (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
^ Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
^ Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
^ Li Y, Graham C, Lacy S, Duncan AM, Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
^ Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. 60 (21): 6171–7. PMID 11085541.

추가 읽기

Akita H (2003). "[Prognostic importance of altered expression of cell cycle regulators in lung cancer]". Nippon Rinsho. 60. Suppl 5: 267–71. PMID 12101670.
Mazumder S, DuPree EL, Almasan A (2004). "A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy". Current Cancer Drug Targets. 4 (1): 65–75. doi:10.2174/1568009043481669. PMC 1307511. PMID 14965268.
Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins". Cell. 70 (6): 993–1006. doi:10.1016/0092-8674(92)90249-C. PMID 1388095. S2CID 30799229.
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. doi:10.1126/science.1388288. PMID 1388288.
Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family". Cell. 66 (6): 1217–28. doi:10.1016/0092-8674(91)90044-Y. PMID 1833068. S2CID 38910227.
Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995). "Human cyclin E, a nuclear protein essential for the G1-to-S phase transition". Mol. Cell. Biol. 15 (5): 2612–24. doi:10.1128/mcb.15.5.2612. PMC 230491. PMID 7739542.
Sewing A, Rönicke V, Bürger C, Funk M, Müller R (1994). "Alternative splicing of human cyclin E.". J. Cell Sci. 107. ( Pt 2) (2): 581–8. doi:10.1242/jcs.107.2.581. PMID 8207080.
Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". J. Virol. 67 (12): 7641–7. doi:10.1128/JVI.67.12.7641-7647.1993. PMC 238233. PMID 8230483.
Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E." Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
Xu X, Burke SP (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.
Ohtani K, DeGregori J, Nevins JR (1996). "Regulation of the cyclin E gene by transcription factor E2F1". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12146–50. doi:10.1073/pnas.92.26.12146. PMC 40313. PMID 8618861.
Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein". Oncogene. 12 (6): 1173–80. PMID 8649818.
Poon RY, Jiang W, Toyoshima H, Hunter T (1996). "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage". J. Biol. Chem. 271 (22): 13283–91. doi:10.1074/jbc.271.22.13283. PMID 8662825.
Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996). "Cyclin-binding motifs are essential for the function of p21CIP1". Mol. Cell. Biol. 16 (9): 4673–82. doi:10.1128/MCB.16.9.4673. PMC 231467. PMID 8756624.
Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.
Won KA, Reed SI (1996). "Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E." EMBO J. 15 (16): 4182–93. doi:10.1002/j.1460-2075.1996.tb00793.x. PMC 452142. PMID 8861947.
Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C (1997). "Activation of human B-MYB by cyclins". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 532–6. doi:10.1073/pnas.94.2.532. PMC 19547. PMID 9012818.
Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R (1997). "Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation". Nucleic Acids Res. 25 (11): 2098–105. doi:10.1093/nar/25.11.2098. PMC 146711. PMID 9153308.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000105173 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000002068 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1833066-5] Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

[entrez-6] "Entrez Gene: CCNE1 cyclin E1".

[pmid9891079-7] ^ ^a ^b ^c ^d ^e ^f Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.

[pmid8617791-8] Xu X, Burke SP (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.

[pmid12529437-9] Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell. 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. PMC 140238. PMID 12529437.

[pmid10500095-10] Singer JD, Gurian-West M, Clurman B, Roberts JM (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.

[pmid1388288-11] Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. doi:10.1126/science.1388288. PMID 1388288.

[pmid12839982-12] McKenzie PP, Danks MK, Kriwacki RW, Harris LC (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. 63 (13): 3840–4. PMID 12839982.

[pmid15004009-13] Mayer C, Zhao J, Yuan X, Grummt I (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.

[pmid10827081-14] Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.

[pmid10581175-15] Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.

[pmid8253383-16] Li Y, Graham C, Lacy S, Duncan AM, Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.

[pmid11085541-17] Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. 60 (21): 6171–7. PMID 11085541.

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사이클린 E1

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기