G2/mitotic 특이 싸이클린-B2 는 인간에서 CCNB2 유전자 에 의해 암호화된 단백질 이다.
함수 사이클린 B2는 사이클린 계열, 특히 B형 사이클린 계열의 일원이다. B형 사이클린 B1과 B2는 p34cdc2와 연관되며 세포주기 규제기계의 필수 구성품이다. B1과 B2는 아세포 국산화에서 차이가 있다. 사이클린 B1은 미세관(microtubule)과 공동 국지화하며, 사이클린 B2는 주로 골기 지역과 관련이 있다. 또한 Cyclin B2는 성장 인자 베타 RII와 결합하므로, Cyclin B2/cdc2는 성장 인자 베타 매개 세포 주기 제어를 변환하는 데 핵심적인 역할을 할 수 있다.[5]
상호작용 사이클린 B2는 TGF 베타 수용체 2 와 상호작용 하는 것으로 나타났다.[6]
참고 항목 참조
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