GL-II-73

GL-II-73
GL-II-73
GL-II-73 structure.png
식별자
  • (4R)-8-ethyl-6-(2-fluorophenyl)-N,N,4-트리메틸-4H-벤조[f]이미다조[1,5-a] [1,4]diazepine-3-카박스아미드
펍켐 CID
화학 및 물리적 데이터
공식C23H19FN4O
어금질량386.1987 g·190−1
3D 모델(JSmol)
  • CN(C)C(=O)c4ncn2c4[C@H](C)N=C(c1cc(C#C)cc12)c3ccc3f
  • InChI=1S/C23H19FN4O/c1-5-15-10-11-19-17(12-15)20(16-8-6-7-9-18(16)24)26-14(2)22-21(23(29)27(3)4)25-13-28(19)22/h1,6-14H,2-4H3/t14-/m1/s1
  • 키:LNPAWXX히우미키-CQZIVSA-N

GL-II-73(GL-i-073)은 화학 구조와 관련된 벤조디아제핀 파생물질로, 미다졸람, 아디나졸람, 라일마자폰의 활성대사물 등의 화합물에 해당된다.α2 및 α에서3 활동성이 약하고 α1 하위타입에 대한 유의미한 친화력이 없는A GABA 수용체 벤조디아제핀 부위의 양성 알로스테리 모듈레이터를 선호하는5 α로 기술된다.동물 실험에서 항우울제, 항불안제 및 비등방성 작용과 일치하는 효과를 생성하는 것으로 밝혀졌다.[1][2][3][4]

참고 항목

참조

  1. ^ CA 3016491, Cook JM, Li G, Poe M, Savic M, Sibille E, "Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists.", published 21 September 2017, assigned to Centre for Addiction and Mental Health, Faculty Of Pharmacy, University of Belgrade and UWM Res Foundation Inc
  2. ^ Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, et al. (January 2018). "Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit" (PDF). bioRxiv: 332908. doi:10.1101/332908. S2CID 90987308.
  3. ^ Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, Cook JM, Savic M, Sibille E (April 2019). "Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles". Molecular Neuropsychiatry. 5 (2): 84–97. doi:10.1159/000496086. PMC 6528097. PMID 31192221.
  4. ^ Sibille E (February 2019). "Brain Inhibitory GABAergic Function and Cognitive Deficits: Mechanisms and Therapeutic Targeting" (PDF). Presentation for AAAS.