FGIN-127

FGIN-127
FGIN-127
FGIN-127 structure.png
식별자
  • 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N, N-di-dihexylacetamide
CAS 번호
펍켐 CID
켐스파이더
체비
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C28H37FN2O
어금질량436.615 g·190−1
3D 모델(JSmol)
  • CCCCCCN(CCCCCCC)C(=O)Cc1c2cc2[nH]c1c3cc(cc3)f
  • InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3 ☒N
  • 키:VUWXAQFLTSB-UHFFFAOYSA-N
☒NcheckY (이게 뭐야?) (iii)

FGIN-1-27은 말초 벤조디아제핀 수용체에서 선택적 작용제 역할을 하는 항불안제제로, 미토콘드리아 18kDa 반역자 단백질 또는 TSPO로도 알려져 있다.알롭기포탄올론 등 신경작용 스테로이드제네시스를 자극해 항불안제 효과를 내는 것으로 생각된다.[1][2][3][4][5][6]

참조

  1. ^ Romeo E, Auta J, Kozikowski AP, Ma D, Papadopoulos V, Puia G, Costa E, Guidotti A (September 1992). "2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)". The Journal of Pharmacology and Experimental Therapeutics. 262 (3): 971–8. PMID 1326631.
  2. ^ Romeo E, Cavallaro S, Korneyev A, Kozikowski AP, Ma D, Polo A, Costa E, Guidotti A (October 1993). "Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex". The Journal of Pharmacology and Experimental Therapeutics. 267 (1): 462–71. PMID 8229777.
  3. ^ Guillon J, Boulouard M, Lelong V, Dallemagne P, Rault S, Jarry C (November 2001). "Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43". The Journal of Pharmacy and Pharmacology. 53 (11): 1561–8. doi:10.1211/0022357011777945. PMID 11732760.
  4. ^ Petralia SM, Frye CA (March 2005). "In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters". Psychopharmacology. 178 (2–3): 174–82. doi:10.1007/s00213-004-2001-9. PMID 15338106.
  5. ^ Opatz T, Ferenc D (September 2006). "Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27". Organic Letters. 8 (20): 4473–5. doi:10.1021/ol061617+. PMID 16986928.
  6. ^ James ML, Selleri S, Kassiou M (2006). "Development of ligands for the peripheral benzodiazepine receptor" (PDF). Current Medicinal Chemistry. 13 (17): 1991–2001. doi:10.2174/092986706777584979. hdl:2158/222808. PMID 16842193.


Stub icon

항불안제에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.