CEACAM5

CEACAM5
사용 가능한 구조물
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1E07, 2QSQ, 2QST, 2VER
식별자
별칭	CEACAM5, CD66e, CEA, 카르시노엠브리오닉 항원 관련 세포 접착 분자 5, CEA 세포 접착 분자 5
외부 ID	OMIM: 114890 호몰로진: 128801 GeneCard: CEACAM5
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	41,730,433 bp
RNA 표현 패턴
	표현된 상단
	결장의; ; 맹장; ; 직장의; ; 지그모이드 결장; ; 횡결장; ; 추골결막;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	GPI 앵커 바인딩; 단백질 호모디메르화 활동; 동일한 단백질 결합;
셀룰러 컴포넌트	막의 고정 성분; 근측 플라스마 막; 플라스마 막의 적분 성분; 세포외 외성체; 막으로 막다; 플라스마 막의 외측 적분 성분; 세포외 지역; 플라즈마 막; 세포표면; 아피셜 플라즈마 막;
생물학적 과정	균질 세포-세포 접착; 세포핵 과정에 대한 부정적인 규제; 아노이키스에 대한 부정적인 규제; 근관 분화에 대한 부정적 규제; C단말단백질 지질화; 백혈구 이동; 사멸적 과정; 세포 접착; 혈장 막 접착 분자를 통한 균질 세포 접착; 플라스마 막 세포 접착 분자를 통한 이질성 세포-세포 접착;
	출처:아미고 / 퀵고
직교체
	1048
	n/a
	ENSG00000105388
	n/a
	P06731
	n/a
	NM_001291484; NM_001308398; NM_004363
	n/a
	NP_001278413; NP_001295327; NP_004354
	n/a
	위키다타
인간 보기/편집

CD66e(Cluster of Dividation 66e)라고도 알려진 카르시노엠브릴론 항원 관련 세포 접착 분자 5(CEACAM5)는 카르시노엠브릴론 항원(CEA) 유전자 계열의 일원이다.^[3]

기능들

문헌에서 CEACAM5는 여러 종류의 악성종양, 대장암 등의 바이오마커로 잘 알려진 암 배아항원(CEA)의 동의어로 자주 쓰인다.^[4]배아장과 대장종양에서 그것의 주된 기능은 상피세포 사이의 유착이다.^[5]또한 대장세포에서 분화와 사멸을 억제하는 데 중요한 역할을 한다.높은 CEACAM5 표현이 CD133 양성 대장암 줄기세포와 확실하게 연관되어 있다는 증거가 있다.^[8]

참고 항목

분화 클러스터

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000105388 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".
^ Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773.
^ Benchimol, Sarita; Fuks, Abraham; Jothy, Serge; Beauchemin, Nicole; Shirota, Kinji; Stanners, Clifford P. (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7.
^ Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.
^ Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.
^ Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615.

추가 읽기

Willcocks TC, Craig IW (November 1990). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, et al. (June 1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology. 10 (6): 2738–2748. doi:10.1128/MCB.10.6.2738. PMC 360634. PMID 2342461.
Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, et al. (August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5350–5354. Bibcode:1987PNAS...84.5350K. doi:10.1073/pnas.84.15.5350. PMC 298853. PMID 2955415.
Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (May 1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2960–2964. Bibcode:1987PNAS...84.2960Z. doi:10.1073/pnas.84.9.2960. PMC 304780. PMID 3033671.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (July 1988). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, et al. (May 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research. 48 (9): 2550–2554. PMID 3356015.
Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP (September 1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology. 7 (9): 3221–3230. doi:10.1128/MCB.7.9.3221. PMC 367958. PMID 3670312.
Oikawa S, Nakazato H, Kosaki G (January 1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications. 142 (2): 511–518. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hart SP, Ross JA, Ross K, Haslett C, Dransfield I (May 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (June 2000). "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity. 68 (6): 3554–3563. doi:10.1128/IAI.68.6.3554-3563.2000. PMC 97642. PMID 10816511.
Boehm MK, Perkins SJ (June 2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters. 475 (1): 11–16. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848. S2CID 5765612.
Screaton RA, DeMarte L, Dráber P, Stanners CP (August 2000). "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology. 150 (3): 613–626. doi:10.1083/jcb.150.3.613. PMC 2175204. PMID 10931872.
Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P (August 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry. 276 (33): 31067–31073. doi:10.1074/jbc.M104093200. PMID 11406629.
Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis. 19 (2): 155–160. doi:10.1023/A:1014566127493. PMID 11964079. S2CID 3138022.
Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer. 101 (6): 545–548. doi:10.1002/ijc.90009. PMID 12237895. S2CID 7030523.
Hampton R, Walker M, Marshall J, Juhl H (November 2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–7823. doi:10.1038/sj.onc.1205906. PMID 12420218.

외부 링크

CEACAM5+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MesH)
UCSC 게놈 브라우저의 인간 CEACAM5 유전체 위치 및 CEACAM5 유전자 세부 정보 페이지.
PDBe-KB는 인간 카르시노엠브릴론 항원 관련 세포 접착 분자 5(CEACAM5)에 대해 PDB에서 이용할 수 있는 모든 구조 정보의 개요를 제공한다.

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

이 막 단백질 관련 기사는 뭉툭하다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000105388 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".

[4] Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773.

[5] Benchimol, Sarita; Fuks, Abraham; Jothy, Serge; Beauchemin, Nicole; Shirota, Kinji; Stanners, Clifford P. (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7.

[6] Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.

[7] Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.

[8] Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615.

[1]

[2]

[3]

[4]

[5]

[8]

v t 단백질: 분화의 군집(인간 분화의 군집 목록 참조)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83년 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158(a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218(a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Search

CEACAM5

네임스페이스

더

목차

기능들

참고 항목

참조

추가 읽기

외부 링크