호모 사피엔스 종의 단백질 코드 유전자
루터 항원 기저세포 접착 분자 는 사람에게서 BCAM [5] 혈장막 당단백질 이다.BCAM도 최근 CD239 (분화 클러스터 239)로 지정되었습니다.
기능. 루터혈액형당단백질은 면역글로불린 슈퍼패밀리의 일원으로 세포외기질단백질인 라미닌 의 수용체이다. 단백질은 5개의 N 말단 , 세포외 면역글로불린 도메인 , 단일 막 통과 도메인 및 짧은 C 말단 세포질 꼬리를 포함합니다. 이 단백질은 상피세포암과 겸상적혈구 질환에서 적혈구의 혈관교합에 역할을 할 수 있다. 이 [5]
상호 작용 BCAM은 알파 [6] [7] 라미닌과 상호작용하는 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000187244 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002980 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)" .^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity" . Blood . 97 (1): 312–20. doi :10.1182/blood.v97.1.312 . PMID 11133776 . ^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo" . J. Biol. 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이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
