TCL1A

TCL1A
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1JSG
식별자
별칭	TCL1A, TCL1, T세포 백혈병/림프종 1A, T세포 백혈병/림프종 1A, TCL1 계열 AKT 공동활성화기 A
외부 ID	OMIM: 186960 MGI: 1097166 호몰로진: 7565 GeneCard: TCL1A
유전자 위치(인간)
쳇.	14번 염색체(인간)
끝	95,714,190 bp
유전자 위치(마우스)
쳇.	12번 염색체(쥐)
끝	105,195,052 bp
RNA 표현 패턴
	표현된 상단
	난모세포; ; 2차 난모세포; ; 림프절; ; 맹장; ; 비장의; ; 핏덩어리; ; 골수; ; 골수 세포; ; 피상 측두동맥; ; 폐골.;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0001948 단백질 결합; 단백질 키나아제 결합; 동일한 단백질 결합; 단백질 세린/트레오닌 키나아제 활성제 활성제;
셀룰러 컴포넌트	세포질; 소포체성 망막; 세포내 막으로 둘러싸인 오르가넬; 핵의; 단백질 함유 복합체;
생물학적 과정	다세포 유기체 개발; 세포 인구 증식에 대한 긍정적인 규제; 미토콘드리아 막 전위의 양성 조절; 단백질 과점제의 양성 규제; 펩티딜-세린 인산화 양성 조절; 세포핵 과정에 대한 부정적인 규제; 단백질 균질화; 종양 괴사 인자에 대한 세포 반응; 단백질 세린/트레오닌 키나아제 활성의 양성 조절;
	출처:아미고 / 퀵고
직교체
	8115
	21432
	ENSG00000100721
	ENSMUSG00000041359
	P56279
	P56280
	NM_001098725; NM_021966
	NM_001289468; NM_009337; NM_001309484; NM_001309485
	NP_001092195; NP_068801; NP_001092195.1; NP_068801.1
	NP_001276397; NP_001296413; NP_001296414; NP_033363
	위키다타
인간 보기/편집	마우스 보기/편집

T세포 백혈병/림프종 단백질 1A는 인간에게 TCL1A 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

상호작용

TCL1A는 AKT1^[8]^[9]^[10] 및 AKT2와 상호작용하는 것으로 나타났다.^[8]^[9]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000100721 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000041359 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
^ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
^ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
^ ^a ^b Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
^ ^a ^b Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
^ French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

추가 읽기

Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849. S2CID 16946256.
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147–55. doi:10.1016/S0969-2126(98)00017-3. PMID 9519406.
Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. doi:10.1111/j.1349-7006.1998.tb03275.x. PMC 5921886. PMID 9738977.
Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.
Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. doi:10.1016/S0165-4608(01)00655-0. PMID 12127395.
Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. Bibcode:2002PNAS...9914392H. doi:10.1073/pnas.212410199. PMC 137894. PMID 12381789.
French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.
Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood. 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313.
Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. Bibcode:2003PNAS..100.4813K. doi:10.1073/pnas.0730710100. PMC 153638. PMID 12672960.

14번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000100721 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000041359 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2783489-5] Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.

[pmid7809072-6] Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.

[entrez-7] "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".

[pmid11707444-8] Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.

[pmid10983986-9] Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

[pmid12009899-10] French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

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TCL1A

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