MTCP1

MTCP1
사용 가능한 구조물
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1A1X, 1QTT, 1QTU
식별자
별칭	MTCP1, P13p8mature T세포 확산 1, 성숙한 T세포 확산 1, TCL1C
외부 ID	OMIM: 300116 호몰로진: 82921 GeneCard: MTCP1
유전자 위치(인간)
쳇.	X염색체(인간)
끝	155,195,937 bp
RNA 표현 패턴
	표현된 상단
	좌심실; ; 근육 조직; ; 하트; ; 결장의; ; 췌장체;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	단백질 키나아제 결합; 단백질 세린/트레오닌 키나아제 활성제 활성제;
셀룰러 컴포넌트	단백질 함유 복합체;
생물학적 과정	세포 인구의 증식; 펩티딜-세린 인산화 양성 조절; 단백질 세린/트레오닌 키나아제 활성의 양성 조절; 세포 인구 증식에 대한 긍정적인 규제;
	출처:아미고 / 퀵고
직교체
	4515
	n/a
	ENSG00000214827
	n/a
	P56278
	n/a
	NM_014221; NM_001018025
	n/a
	NP_001018025
	n/a
	위키다타
인간 보기/편집

단백질 p13 MTCP-1은 인간에서 MTCP1 유전자에 의해 암호화된 단백질이다.^[3]^[4]^[5]^[6]

함수

이 유전자는 성숙한 T-세포 증식과 관련된 일부 t(X;14) 번역에 관여함으로써 확인되었다.이 유전자는 두 개의 서로 다른 단백질을 암호화하는 두 개의 ORF를 가지고 있다.업스트림 ORF는 TCL1 계열의 구성원인 13kDa 단백질을 인코딩한다. 이 단백질은 백혈구 발생에 관여할 수 있다.다운스트림 ORF는 미토콘드리아에 국소화하는 8kDa 단백질을 암호화한다.대체 스플라이싱은 여러 대본을 변형하는 결과를 낳는다.^[6]

상호작용

MTCP1은 AKT1과 상호작용하는 것으로 나타났다.^[7]^[8]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000214827 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.
^ Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. doi:10.1182/blood.V87.5.1923.1923. PMID 8634440.
^ Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR. 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281. S2CID 22862333.
^ ^a ^b "Entrez Gene: MTCP1 mature T-cell proliferation 1".
^ Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

추가 읽기

Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein". Oncogene. 10 (11): 2259–62. PMID 7784073.
Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation". Oncogene. 9 (12): 3565–70. PMID 7970717.
Thick J, Mak YF, Metcalfe J, Beatty D, Taylor AM (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia. 8 (4): 564–73. PMID 8152252.
Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene. 8 (12): 3271–6. PMID 8247530.
Gritti C, Choukroun V, Soulier J, Madani A, Dastot H, Leblond V, Radford-Weiss I, Valensi F, Varet B, Sigaux F, Stern MH (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations". Oncogene. 15 (11): 1329–35. doi:10.1038/sj.onc.1201303. PMID 9315101.
Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif" (PDF). J. Mol. Biol. 274 (5): 801–15. doi:10.1006/jmbi.1997.1438. PMID 9405159.
Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Varnum J, Germann MW, Croce CM (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins". Protein Expr. Purif. 12 (2): 215–25. doi:10.1006/prep.1997.0822. PMID 9518463.
Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW (1998). "Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. Bibcode:1998PNAS...95.3413F. doi:10.1073/pnas.95.7.3413. PMC 19850. PMID 9520380.
Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data". J. Biomol. NMR. 17 (3): 215–30. doi:10.1023/A:1008386110930. PMID 10959629. S2CID 46115803.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

인간 X 염색체 및/또는 그 관련 단백질에 대한 유전자에 대한 이 기사는 스터브다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000214827 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8361760-3] Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.

[pmid8634440-4] Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. doi:10.1182/blood.V87.5.1923.1923. PMID 8634440.

[pmid9691281-5] Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR. 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281. S2CID 22862333.

[entrez-6] "Entrez Gene: MTCP1 mature T-cell proliferation 1".

[pmid11707444-7] Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.

[pmid10983986-8] Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

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MTCP1

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상호작용

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