RXFP2 라고도 알려진 Relaxin/Insulin 유사 가족 펩타이드 수용체 2 는 인간 G-단백 결합 수용체 다.[5]
엽상 자극 호르몬 (FSH; MIM 136530 참조)과 갑상선 자극 호르몬 (TSH; MIM 188540 참조)과 같은 당단백질 호르몬 수용체는 큰 N-단자외 영역을 가진 G단백질 결합 7-트랜섬브레인 수용체(GPCR)이다.LRR(Leucine-rich repeat )-LGR(Leucine-rich repeat, LRR)이 GPCR 슈퍼 패밀리의 하위 그룹을 형성한다. [[5]
참고 항목 참조 추가 읽기 Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci . 1041 : 61–76. doi :10.1196/annals.1282.010 . PMID 15956688 . S2CID 1185573 . Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev . 58 (1): 7–31. doi :10.1124/pr.58.1.9 . PMID 16507880 . S2CID 7466039 . Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science . 295 (5555): 671–4. doi :10.1126/science.1065654 . PMID 11809971 . S2CID 32693420 . Kumagai J, Hsu SY, Matsumi H, et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent" . J. Biol. Chem . 277 (35): 31283–6. doi :10.1074/jbc.C200398200 PMID 12114498 . Gorlov IP, Kamat A, Bogatcheva NV, et al. (2003). "Mutations of the GREAT gene cause cryptorchidism" . Hum. Mol. Genet . 11 (19): 2309–18. doi :10.1093/hmg/11.19.2309 PMID 12217959 . Sudo S, Kumagai J, Nishi S, et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2" . J. Biol. Chem . 278 (10): 7855–62. doi :10.1074/jbc.M212457200 PMID 12506116 . Ferlin A, Simonato M, Bartoloni L, et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism" . J. Clin. Endocrinol. Metab . 88 (9): 4273–9. doi :10.1210/jc.2003-030359 PMID 12970298 . Roh J, Virtanen H, Kumagai J, et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism" . Reprod. Biomed. Online . 7 (4): 400–6. doi :10.1016/S1472-6483(10)61883-4 PMID 14656401 . Vinci G, Anjot MN, Trivin C, et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia" . J. Clin. Endocrinol. Metab . 89 (12): 6282–5. doi :10.1210/jc.2004-0891 PMID 15579790 . Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor" . J. Biol. Chem . 280 (15): 14586–90. doi :10.1074/jbc.M414443200 PMID 15708846 . Muda M, He C, Martini PG, et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity" . Mol. Hum. Reprod . 11 (8): 591–600. doi :10.1093/molehr/gah205 PMID 16051677 . Rosengren KJ, Zhang S, Lin F, et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3" . J. Biol. Chem . 281 (38): 28287–95. doi :10.1074/jbc.M603829200 PMID 16867980 . Bogatcheva NV, Ferlin A, Feng S, et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane" . Am. J. Physiol. Endocrinol. Metab . 292 (1): E138–44. doi :10.1152/ajpendo.00228.2006 . PMID 16926383 . S2CID 17442101 . Scott DJ, Layfield S, Yan Y, et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules" . J. Biol. Chem . 281 (46): 34942–54. doi :10.1074/jbc.M602728200 PMID 16963451 . El Houate B, Rouba H, Sibai H, et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism". J. Urol . 177 (5): 1947–51. doi :10.1016/j.juro.2007.01.002 . PMID 17437853 . Scott DJ, Wilkinson TN, Zhang S, et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3" . Mol. Endocrinol . 21 (7): 1699–712. doi :10.1210/me.2007-0097 PMID 17473281 . 외부 링크 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
