SB-216641

SB-216641
SB-216641
SB-216,641 structure.png
임상자료
ATC 코드
  • 없는
식별자
  • N-[3-[3-[3-(디메틸아미노)에톡시]-4-메톡시페닐]-2'-메틸-4'-(5-메틸-1,2,4-옥사디아졸-3-yl)-[1,1'-비페닐]-4-카박스아미드
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
유니
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C28H30N4O4
어금질량486.572 g·190−1
3D 모델(JSmol)
  • CN(C)CC1cc(ccc1OC)NC(=O)c3cc(cc3)-c2cc(cc2C)-c4noc(C)n4
  • InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33)
  • 키:JRNUKVFYILMMLX-UHFFFAOYSA-N
(iii)

SB-216641은 세로토닌 수용체 5-HT의1B 선택적 길항제인 약물로 밀접하게 연관된 5-HT1D 수용체보다 약 25배 선택성이 있다.[1] 과학 연구에 사용되며,[2][3][4] 동물 연구에서 불안요인 효과를 입증해 왔다.[5][6]

참조

  1. ^ Price GW, Burton MJ, Collin LJ, Duckworth M, Gaster L, Göthert M, et al. (September 1997). "SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 356 (3): 312–20. doi:10.1007/PL00005056. PMID 9303567. S2CID 26760453.
  2. ^ Matsuoka T, Hasuo H, Akasu T (March 2004). "5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus". Neuroscience Research. 48 (3): 229–38. doi:10.1016/j.neures.2003.11.004. PMID 15154669. S2CID 35850798.
  3. ^ Yan QS, Zheng SZ, Yan SE (September 2004). "Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis". Brain Research. 1021 (1): 82–91. doi:10.1016/j.brainres.2004.06.053. PMID 15328035. S2CID 46700479.
  4. ^ Lee JJ, Hahm ET, Lee CH, Cho YW (January 2008). "Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons". Neuropsychopharmacology. 33 (2): 340–52. doi:10.1038/sj.npp.1301396. PMID 17392733.
  5. ^ Tatarczyńska E, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E (December 2004). "Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression". Behavioural Pharmacology. 15 (8): 523–34. doi:10.1097/00008877-200412000-00001. PMID 15577451. S2CID 6940756.
  6. ^ Chojnacka-Wójcik E, Kłodzińska A, Tatarczyńska E (February 2005). "The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action". The Journal of Pharmacy and Pharmacology. 57 (2): 253–7. doi:10.1211/0022357055399. PMID 15720791. S2CID 20743875.
Stub icon

신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.