DUSP1
DUSP1
이중특이성 단백질인산화효소 1은 인간에서 DUSP1 유전자에 의해 암호화된 효소다.[5][6]
함수
DUSP1 유전자의 발현은 산화/열 응력과 성장 인자에 의해 인간의 피부 섬유질에서 유도된다.비수용체형 단백질-티로신인산효소 계열의 구성원과 유사한 구조적 특징을 가진 단백질을 지정하며, 백신 바이러스의 고 유전자 H1에 의해 인코딩된 Tyr/Ser-단백질인산효소와 상당한 아미노산 염기서열 유사성을 가진다.박테리아로 표현되고 정제된 DUSP1 단백질은 내인성 인지효소 활성을 가지고 있으며, 특히 미토겐 활성 단백질(MAP) 키나제는 그것의 인광 레오닌과 인광티로신 잔류물의 결합제 탈인산화 작용에 의해 시험관내 미토겐 활성 단백질(MAP) 키나제를 불활성화한다.나아가 Xenopus 난모세포 추출물에서 인공적인 ras에 의한 MAP키나아제의 활성화를 억제한다.따라서 DUSP1은 환경 스트레스에 대한 인간의 세포 반응과 세포 증식의 부정적인 규제에서 중요한 역할을 할 수 있다.[7]
상호작용
DUSP1은 MAPK14,[8][9] MAPK1[9][10] 및 MAPK8과 상호작용하는 것으로 나타났다.[9]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000120129 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000024190 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Keyse SM, Emslie EA (Oct 1992). "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase". Nature. 359 (6396): 644–7. doi:10.1038/359644a0. PMID 1406996. S2CID 4307895.
- ^ Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jul 1994). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases" (PDF). Genomics. 22 (2): 462–4. doi:10.1006/geno.1994.1411. hdl:2027.42/31442. PMID 7806236.
- ^ "Entrez Gene: DUSP1 dual specificity phosphatase 1".
- ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". The Journal of Biological Chemistry. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
- ^ a b c Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry. 276 (19): 16491–500. doi:10.1074/jbc.M010966200. PMID 11278799.
- ^ Calvisi DF, Pinna F, Meloni F, Ladu S, Pellegrino R, Sini M, Daino L, Simile MM, De Miglio MR, Virdis P, Frau M, Tomasi ML, Seddaiu MA, Muroni MR, Feo F, Pascale RM (Jun 2008). "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma". Cancer Research. 68 (11): 4192–200. doi:10.1158/0008-5472.CAN-07-6157. PMID 18519678.
추가 읽기
- Martell KJ, Angelotti T, Ullrich A (Feb 1998). "The "VH1-like" dual-specificity protein tyrosine phosphatases". Molecules and Cells. 8 (1): 2–11. PMID 9571625.
- Keyse SM (Apr 1998). "Protein phosphatases and the regulation of MAP kinase activity". Seminars in Cell & Developmental Biology. 9 (2): 143–52. doi:10.1006/scdb.1997.0219. PMID 9599409.
- Abraham SM, Clark AR (Dec 2006). "Dual-specificity phosphatase 1: a critical regulator of innate immune responses". Biochemical Society Transactions. 34 (Pt 6): 1018–23. doi:10.1042/BST0341018. PMID 17073741.
- Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ (Mar 1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". The Journal of Biological Chemistry. 270 (13): 7420–6. doi:10.1074/jbc.270.13.7420. PMID 7535770.
- Kwak SP, Hakes DJ, Martell KJ, Dixon JE (Feb 1994). "Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene". The Journal of Biological Chemistry. 269 (5): 3596–604. doi:10.1016/S0021-9258(17)41905-3. PMID 8106404.
- Emslie EA, Jones TA, Sheer D, Keyse SM (May 1994). "The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34". Human Genetics. 93 (5): 513–6. doi:10.1007/BF00202814. PMID 8168826. S2CID 12590731.
- Sun H, Charles CH, Lau LF, Tonks NK (Nov 1993). "MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo". Cell. 75 (3): 487–93. doi:10.1016/0092-8674(93)90383-2. PMID 8221888. S2CID 29988777.
- Charles CH, Sun H, Lau LF, Tonks NK (Jun 1993). "The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 90 (11): 5292–6. doi:10.1073/pnas.90.11.5292. PMC 46702. PMID 8389479.
- Alessi DR, Smythe C, Keyse SM (Jul 1993). "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts". Oncogene. 8 (7): 2015–20. PMID 8390041.
- Brondello JM, Pouysségur J, McKenzie FR (Dec 1999). "Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation". Science. 286 (5449): 2514–7. doi:10.1126/science.286.5449.2514. PMID 10617468.
- Hutter D, Chen P, Barnes J, Liu Y (Nov 2000). "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation". The Biochemical Journal. 352 (1): 155–63. doi:10.1042/0264-6021:3520155. PMC 1221442. PMID 11062068.
- Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry. 276 (19): 16491–500. doi:10.1074/jbc.M010966200. PMID 11278799.
- Manzano RG, Montuenga LM, Dayton M, Dent P, Kinoshita I, Vicent S, Gardner GJ, Nguyen P, Choi YH, Trepel J, Auersperg N, Birrer MJ (Jun 2002). "CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential". Oncogene. 21 (28): 4435–47. doi:10.1038/sj.onc.1205542. PMID 12080474.
- Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD (Dec 2002). "Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2". The Journal of Biological Chemistry. 277 (49): 47444–50. doi:10.1074/jbc.M208140200. PMID 12356755.
- Lasa M, Abraham SM, Boucheron C, Saklatvala J, Clark AR (Nov 2002). "Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38". Molecular and Cellular Biology. 22 (22): 7802–11. doi:10.1128/MCB.22.22.7802-7811.2002. PMC 134716. PMID 12391149.
- Denkert C, Schmitt WD, Berger S, Reles A, Pest S, Siegert A, Lichtenegger W, Dietel M, Hauptmann S (Dec 2002). "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal of Cancer. 102 (5): 507–13. doi:10.1002/ijc.10746. PMID 12432554. S2CID 45750943.
