E3 유비퀴틴-단백질 연결효소 SIAH1은 SIAH1 [5] [6] 효소 이다.
기능. 이 유전자는 7가지 결석 호몰로그(SIAH) 계열의 멤버인 폴리펩타이드 구조를 암호화한다. 단백질은 E3 연결효소 이며 특정 단백질의 유비퀴티네이션 및 프로테아솜 매개 분해에 관여합니다. 이 유비퀴틴 연결효소의 활성은 파킨슨병의 특정 형태의 발병, 저산소증 에 대한 세포 반응 조절 및 아포토시스 유도와 관련이 있다. 대체 스플라이싱으로 인해 여러 개의 추가 트랜스크립트 변형이 발생하며, 일부는 서로 다른 Isoforms를 인코딩하고 다른 일부는 완전히 [7]
상호 작용 SIAH1은 다음과 상호작용하는 것 으로 나타났습니다.
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PDB 갤러리
2a25 : SIP에서 펩타이드 EKPAVAPAPITG에 결합하는 Siah1 SBD의 결정구조
