Zyxin 은 인간에게서 ZYX [5] [6] [7] 유전자 에 의해 암호화되는 단백질 이다.
기능. 국소 접착 은 세포가 세포외 기질에 부착할 수 있게 하고 신호 전달에 관여하는 단백질 복합체가 모이는 액틴이 풍부한 구조입니다.Zyxin은 아연 결합 인단백질이며, 초점 접착과 액틴 세포 골격을 따라 농축됩니다. Zyxin은 N 말단 프롤린 리치 도메인과 C 말단 절반에 3개의 LIM 도메인을 가지고 있다. 프롤린이 풍부한 도메인은 신호 전달 경로에 관여하는 단백질의 SH3 도메인과 상호작용할 수 있는 반면, LIM 도메인은 단백질-단백질 결합에 관여할 가능성이 있다. Zyxin은 유전자 발현에서 접착 자극 변화를 매개하는 신호 전달 경로에서 전달자로 기능할 수 있으며 액틴 다발의 세포 골격 구조를 변조할 수 있다. 대체 스플라이싱을 사용하면 동일한 Isoform을 [7]
상호 작용 Zyxin은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c ENSG00000285443 GRCh38: 앙상블 릴리즈 89: ENSG00000159840, ENSG00000285443 - Ensembl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029860 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zumbrunn J, Trueb B (January 1997). "A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts" . Eur J Biochem . 241 (2): 657–63. doi :10.1111/j.1432-1033.1996.00657.x PMID 8917469 . ^ Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC (January 1997). "Molecular characterization of human zyxin" . J Biol Chem . 271 (49): 31470–8. doi :10.1074/jbc.271.49.31470 PMID 8940160 . ^ a b "Entrez Gene: ZYX zyxin" .^ Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B (May 1999). "An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment" . J. Biol. Chem . 274 (19): 13410–8. doi :10.1074/jbc.274.19.13410 PMID 10224105 . ^ Li B, Trueb B (September 2001). "Analysis of the alpha-actinin/zyxin interaction" . J. Biol. Chem . 276 (36): 33328–35. doi :10.1074/jbc.M100789200 PMID 11423549 . ^ Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase" . J. Biol. Chem . 278 (24): 21685–92. doi :10.1074/jbc.M301447200 PMID 12672821 . ^ a b Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins" . J. Biol. Chem . 275 (29): 22503–11. doi :10.1074/jbc.M001698200 PMID 10801818 . ^ Li B, Zhuang L, Trueb B (May 2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1" . J. Biol. Chem . 279 (19): 20401–10. doi :10.1074/jbc.M310304200 PMID 15004028 . ^ Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H (May 2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor" . J. Cell Biol . 149 (5): 1073–86. doi :10.1083/jcb.149.5.1073 . PMC 2174824 PMID 10831611 . ^ Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin" . J. Biol. Chem . 275 (40): 30817–25. doi :10.1074/jbc.M005066200 PMID 10882740 . 추가 정보 Reinhard M, Jouvenal K, Tripier D, Walter U (1995). "Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein)" . Proc. Natl. Acad. Sci. U.S.A . 92 (17): 7956–60. doi :10.1073/pnas.92.17.7956 PMC 41265 PMID 7644520 . Wang LF, Miao SY, Zong SD, Bai Y, Koide SS (1995). "Gene encoding a mammalian epididymal protein". Biochem. Mol. Biol. Int . 34 (6): 1131–6. PMID 7696985 . Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal B (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene . 12 (7): 1577–81. PMID 8622875 . Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S (1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells" . J. Biol. Chem . 272 (47): 29407–10. doi :10.1074/jbc.272.47.29407 PMID 9367993 . Zumbrunn J, Trueb B (1998). "Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34→q35 by in situ hybridization". Cytogenet. Cell Genet . 81 (3–4): 283–4. doi :10.1159/000015047 . PMID 9730620 . S2CID 46778049 . Yang JX, Miao SY, Wu YW, Zhang Z, Zong SD, Wang LF, Koide SS (1998). "Gene encoding a human testis Sertoli cell component related to LIM domain protein" . Biochem. Mol. Biol. Int . 46 (1): 11–9. doi :10.1080/15216549800203502 PMID 9784834 . S2CID 6735908 . Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B (1999). "An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment" . J. Biol. Chem . 274 (19): 13410–8. doi :10.1074/jbc.274.19.13410 PMID 10224105 . Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins" . J. Biol. Chem . 275 (29): 22503–11. doi :10.1074/jbc.M001698200 PMID 10801818 . Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H (2000). "Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor" . J. Cell Biol . 149 (5): 1073–86. doi :10.1083/jcb.149.5.1073 . PMC 2174824 PMID 10831611 . Smolenski A, Poller W, Walter U, Lohmann SM (2000). "Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I" . J. Biol. Chem . 275 (33): 25723–32. doi :10.1074/jbc.M909632199 PMID 10851246 . Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S (2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin" . J. Biol. Chem . 275 (40): 30817–25. doi :10.1074/jbc.M005066200 PMID 10882740 . Schenker T, Trueb B (2000). "BSPRY, a novel protein of the Ro-Ret family". Biochim. Biophys. Acta . 1493 (1–2): 255–8. doi :10.1016/s0167-4781(00)00167-6 . PMID 10978534 . Li B, Trueb B (2001). "Analysis of the alpha-actinin/zyxin interaction" . J. Biol. Chem . 276 (36): 33328–35. doi :10.1074/jbc.M100789200 PMID 11423549 . Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human Papillomavirus Type 6 Results in Its Nuclear Translocation" . J. Virol . 75 (23): 11791–802. doi :10.1128/JVI.75.23.11791-11802.2001 . PMC 114765 PMID 11689660 . Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers" . J. Biol. Chem . 277 (11): 9580–9. doi :10.1074/jbc.M106922200 PMID 11782456 . van der Gaag EJ, Leccia MT, Dekker SK, Jalbert NL, Amodeo DM, Byers HR (2002). "Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes" . J. Invest. Dermatol . 118 (2): 246–54. doi :10.1046/j.0022-202x.2001.01657.x PMID 11841540 .
외부 링크 
