11-히드록시-THC

11-Hydroxy-THC
11-히드록시-THC
11-OH-THC.svg
11-Hydroxy-THC molecule
식별자
  • (6aR,10aR)-9-(Hydroxymethyl)-6,6-dimethyl-3-pentil-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
CAS 번호
펍켐 CID
켐스파이더
유니
CompTox 대시보드 (EPA)
ECHA InfoCard100.164.583 Edit this at Wikidata
화학 및 물리적 데이터
공식C21H30O3
어금질량330.468 g·1998−1
3D 모델(JSmol)
  • Oc2cc(cc1OC(C3CC/C(=C\C3c12)CO)(C)CCC
  • InChI=1S/C21H30O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h10-12,16-17,22-23H,4-9,13H2,1-3H3 checkY
  • 키:YCBKSSAUDACY-UHFFFAOYSA-N checkY
☒NcheckY (이게 뭐야?) (iii)

11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC, alternatively numbered as 7-OH-Δ1-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after decarboxylated cannabis is consumed.[1][2]

신선한 대마초는 테트라하이드로카나비놀산(TCA)을 함유하고 있는데, 이것은 가열 후 THC로 변환되어 신체에 의해 11-hydroxy-THC로 대사된 다음 11-nor-9-carboxy-THC로 흡수된다.[2] 두 화합물 모두 글루쿠론화 될 수 있고 주로 소변으로 배설된다. 두 화합물은 THC와 함께 혈액 검사에서 분석된다.[1]

11-hydroxy-THC는 THC와 유사한 정신 활성 효과를 가지지만, 효과의 시작은 더 느리다.[medical citation needed][3]

참고 항목

참조

  1. ^ a b Kraemer T, Paul LD (August 2007). "Bioanalytical procedures for determination of drugs of abuse in blood". Analytical and Bioanalytical Chemistry. 388 (7): 1415–35. doi:10.1007/s00216-007-1271-6. PMID 17468860. S2CID 32917584.
  2. ^ a b Huestis MA (2005). "Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol". Handbook of Experimental Pharmacology. 168 (168): 657–90. doi:10.1007/3-540-26573-2_23. ISBN 3-540-22565-X. PMID 16596792.
  3. ^ Lemberger, L.; Martz, R.; Rodda, B.; Forney, R.; Rowe, H. (1973). "Comparative Pharmacology of Δ9-Tetrahydrocannabinol and its Metabolite, 11-OH-Δ9-Tetrahydrocannabinol". The Journal of Clinical Investigation. 52 (10): 2411–2417. doi:10.1172/JCI107431. PMC 302499. PMID 4729039.