11-히드록시카나비놀

11-Hydroxycannabinol
11-히드록시카나비놀
11-OH-CBN structure.png
식별자
  • 9-(히드록시메틸)-6,6-디메틸-3-펜틸벤조[c]디모멘-1-ol
CAS 번호
PubChem CID
첸블
CompTox 대시보드 (EPA )
화학 및 물리 데이터
공식C21H26O3
몰 질량326.436 g/120−1
3D 모델(JSmol)
  • CCCCC1=CC(=C2C(=C1)OC(C3=C2C=C3)CO)(C)C)O
  • InChI=1S/C21H26O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h8-12,22-23H4-13,13,2
  • 키 : YDKZOUNVEIGJPO-UHFFFAOYSA-N

11-히드록시카나비놀(11-OH-CBN)은 대마초의 활성 성분 중 하나인 칸나비놀(CBN)[1]의 주요 활성 대사물이며 대마 자체로부터 [2]분리되었다.CBN 자체보다 강력하여 THC와 거의 동일한 효력을 가진 CB의1 작용제 역할을 하지만 [3][4]CB에서는 약한2 길항제이다.

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레퍼런스

  1. ^ Yamamoto I, Kuzuoka K, Watanabe K, Narimatsu S, Yoshimura H (1988). "Metabolic formation and pharmacological effects of 11-hydroxycannabinol, an active metabolite of cannabinol.". In Chesher G, Consroe P, Musty R (eds.). Marihuana: an international research report. National Campaign Against Drug Abuse, monograph series No. 7. Canberra: Australian Government Printing Office. pp. 135–140.
  2. ^ de A Leite J, de Oliveira MV, Conti R, de S Borges W, Rosa TR, Filgueiras PR, Lacerda V, Romão W, Neto ÁC (September 2018). "Extraction and isolation of cannabinoids from marijuana seizures and characterization by 1H NMR allied to chemometric tools". Science & Justice. 58 (5): 355–365. doi:10.1016/j.scijus.2018.06.005. PMID 30193661.
  3. ^ Yamamoto I, Watanabe K, Kuzuoka K, Narimatsu S, Yoshimura H (May 1987). "The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol". Chemical & Pharmaceutical Bulletin. 35 (5): 2144–7. doi:10.1248/cpb.35.2144. PMID 3664823.
  4. ^ Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L, et al. (September 1997). "Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase". Journal of Medicinal Chemistry. 40 (20): 3228–33. doi:10.1021/jm970126f. PMID 9379442.


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