호모 사피엔스 종의 단백질 코드 유전자
M상유도인자 포스파타아제3 은 CDC25C [5] 효소 이다.
이 유전자는 진화 과정에서 고도로 보존되며 세포 분열 조절에 중요한 역할을 한다. 암호화된 단백질은 티로신 포스파타아제이며 Cdc25 포스파타아제 계열에 속합니다. 그것은 사이클린 B 결합 CDC2(CDK1)의 탈인화를 유도하고 유사분열을 유발한다. 또한 p53에 의한 성장 정지를 억제하는 것으로 생각된다. 이 유전자의 복수의 대체 스플라이스된 전사 변이체가 기술되어 왔지만, 이들 중 많은 유전자의 전장 성질은 알려져 [6]
상호 작용 CDC25C는 MAPK14 ,[7] CHEK1 ,[8] PCNA ,[9] PIN1 ,[10] [11] [12] PLK3 [13] 및 NEDD4와 [12] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000158402 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000044201 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science . 250 (4987): 1573–6. Bibcode :1990Sci...250.1573G . doi :10.1126/science.1703321 . PMID 1703321 . S2CID 25037148 . ^ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)" .^ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature 411 (6833): 102–7. doi :10.1038/35075107 . ISSN 0028-0836 . PMID 11333986 . 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