PAWR

PAWR
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2JK9
식별자
에일리어스	PAWR, Pawr, 2310001G03Rik, PAR4, PAR-4, 프로아포토시스 WT1 레귤레이터
외부 ID	OMIM: 601936 MGI: 2149961 HomoloGene: 1940 GeneCards: PAWR
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	79,690,964 bp
유전자 위치(마우스)
크르.	10번 염색체(쥐)
끝.	108,250,101 bp
RNA발현패턴
	상단 표시 위치:
	생식 상피; ; 복정맥; ; 우관상 동맥; ; 상부 신경; ; 좌측 자궁관; ; 근막; ; 두정 흉막; ; 좌관상동맥; ; 부고환 말뭉치; ; 자궁경관;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001106 전사 코어프레서 액티비티; 류신 지퍼 도메인 결합; GO:0001948 단백질 결합; 효소결합; 액틴 결합;
셀룰러 컴포넌트	세포질; 핵; 액틴 필라멘트;
생물학적 과정	전사조절, DNA템플릿화; 전사, DNA 템플릿; 액틴 필라멘트 다발 조립체; T세포수용체신호경로음성조절; T세포 증식의 음성 조절; 아밀로이드 전구체 단백질 생합성 과정의 양성 조절; 아포토시스 신호 경로; B세포 증식의 음성 조절; 아포토시스 과정; 유전자 발현 음성 조절; RNA중합효소II에 의한 전사 음성 조절; 세포 노화의 양성 조절; 유전자 발현 양성 조절; 섬유아세포 증식의 음성 조절; 과산화수소프로그래밍세포사 양성조절; 아포토시스 과정의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	5074
	114774
	ENSG00000177425
	ENSMUSG000035873
	Q96IZ0
	Q925B0
	NM_002583; NM_001354732; NM_001354733
	NM_054056
	NP_002574; NP_001341661; NP_001341662
	NP_473397
	위키데이터
인간 보기/편집	마우스 표시/편집

PRKC, 아포토시스, WT1, 조절기, PAWR 또는 전립선 아포토시스 반응-4(Par-4)라고도 알려진 조절기는 암세포에서 아포토시스를 유도하는 종양억제단백질을 코드하는 인간 유전자이다.

기능.

종양 억제제 WT1은 전사를 억제하고 활성화합니다.이 유전자에 의해 암호화된 단백질은 WT1-상호작용 단백질로, 그 자체가 전사억제제 역할을 한다.WT1의 아연 핑거 DNA 결합 도메인과 상호작용하는 추정 류신 지퍼 도메인을 포함한다.이 단백질은 특히 전립선 ^[5]세포의 세포사멸 동안 상향 조절된다.Par-4 단백질의 활성 도메인은 정상적인 생존력이나 노화를 저해하지 않고 유전자 변환 생쥐에서 암 내성을 부여하는 것으로 밝혀졌으며 치료적 ^[6]의미를 가질 수 있다.

상호 작용

PAWR은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000177425 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035873 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PAWR PRKC, apoptosis, WT1, regulator".
^ Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, Spear B, Rangnekar VM (Oct 2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Research. 67 (19): 9276–85. doi:10.1158/0008-5472.CAN-07-2124. PMID 17909035.
^ Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
^ Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/mcb.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
^ Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J (Sep 1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C". Cell. 86 (5): 777–86. doi:10.1016/s0092-8674(00)80152-x. PMID 8797824. S2CID 15675524.
^ Xie J, Guo Q (Jul 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane". The Journal of Biological Chemistry. 279 (27): 28266–75. doi:10.1074/jbc.M401495200. PMID 15090548.
^ Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP (Apr 2003). "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies". Oncogene. 22 (16): 2432–42. doi:10.1038/sj.onc.1206271. PMID 12717420.
^ Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, Haber DA, Licht JD, Sugrue SP, Roberts T, Rangnekar VM, Shi Y (Dec 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Molecular and Cellular Biology. 16 (12): 6945–56. doi:10.1128/mcb.16.12.6945. PMC 231698. PMID 8943350.

추가 정보

El-Guendy N, Rangnekar VM (Feb 2003). "Apoptosis by Par-4 in cancer and neurodegenerative diseases". Experimental Cell Research. 283 (1): 51–66. doi:10.1016/S0014-4827(02)00016-2. PMID 12565819.
Bieberich E, MacKinnon S, Silva J, Noggle S, Condie BG (Aug 2003). "Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide". The Journal of Cell Biology. 162 (3): 469–79. doi:10.1083/jcb.200212067. PMC 2172704. PMID 12885759.
Gurumurthy S, Rangnekar VM (Feb 2004). "Par-4 inducible apoptosis in prostate cancer cells". Journal of Cellular Biochemistry. 91 (3): 504–12. doi:10.1002/jcb.20000. PMID 14755681. S2CID 31578703.
Ranganathan P, Rangnekar VM (Nov 2005). "Regulation of cancer cell survival by Par-4". Annals of the New York Academy of Sciences. 1059: 76–85. doi:10.1196/annals.1339.046. PMID 16382046. S2CID 26538481.
Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J (Sep 1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C". Cell. 86 (5): 777–86. doi:10.1016/S0092-8674(00)80152-X. PMID 8797824. S2CID 15675524.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, Haber DA, Licht JD, Sugrue SP, Roberts T, Rangnekar VM, Shi Y (Dec 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Molecular and Cellular Biology. 16 (12): 6945–56. doi:10.1128/mcb.16.12.6945. PMC 231698. PMID 8943350.
Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, Bondada V, Rangnekar VM, Mattson MP (Aug 1998). "Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease". Nature Medicine. 4 (8): 957–62. doi:10.1038/nm0898-957. PMID 9701251. S2CID 1621858.
Johnstone RW, Tommerup N, Hansen C, Vissing H, Shi Y (Oct 1998). "Mapping of the human PAWR (par-4) gene to chromosome 12q21". Genomics. 53 (2): 241–3. doi:10.1006/geno.1998.5494. PMID 9790775.
Kruman II, Nath A, Maragos WF, Chan SL, Jones M, Rangnekar VM, Jakel RJ, Mattson MP (Jul 1999). "Evidence that Par-4 participates in the pathogenesis of HIV encephalitis". The American Journal of Pathology. 155 (1): 39–46. doi:10.1016/s0002-9440(10)65096-1. PMC 1866661. PMID 10393834.
Guo Q, Xie J, Chang X, Du H (May 2001). "Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway". The Journal of Biological Chemistry. 276 (19): 16040–4. doi:10.1074/jbc.M010996200. PMID 11278808.
Chakraborty M, Qiu SG, Vasudevan KM, Rangnekar VM (Oct 2001). "Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression". Cancer Research. 61 (19): 7255–63. PMID 11585763.
Chang S, Kim JH, Shin J (Jan 2002). "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition". FEBS Letters. 510 (1–2): 57–61. doi:10.1016/S0014-5793(01)03224-0. PMID 11755531. S2CID 85579338.
Ohki R, Yamamoto K, Mano H, Lee RT, Ikeda U, Shimada K (Apr 2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". Journal of Hypertension. 20 (4): 685–91. doi:10.1097/00004872-200204000-00026. PMID 11910304. S2CID 34968458.
Hsu SC, Kirschenbaum F, Miller J, Cordell B, McCarthy JV (Jul 2002). "Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4". Gene. 295 (1): 109–16. doi:10.1016/S0378-1119(02)00826-0. PMID 12242017.
Cheema SK, Mishra SK, Rangnekar VM, Tari AM, Kumar R, Lopez-Berestein G (May 2003). "Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter". The Journal of Biological Chemistry. 278 (22): 19995–20005. doi:10.1074/jbc.M205865200. PMID 12644474.
Boehrer S, Chow KU, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E (Sep 2002). "Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells". Leukemia & Lymphoma. 43 (9): 1737–41. doi:10.1080/1042819021000006510. PMID 12685825. S2CID 45232765.
Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP (Apr 2003). "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies". Oncogene. 22 (16): 2432–42. doi:10.1038/sj.onc.1206271. PMID 12717420.
El-Guendy N, Zhao Y, Gurumurthy S, Burikhanov R, Rangnekar VM (Aug 2003). "Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells". Molecular and Cellular Biology. 23 (16): 5516–25. doi:10.1128/MCB.23.16.5516-5525.2003. PMC 166354. PMID 12897127.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000177425 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000035873 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PAWR PRKC, apoptosis, WT1, regulator".

[6] Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, Spear B, Rangnekar VM (Oct 2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Research. 67 (19): 9276–85. doi:10.1158/0008-5472.CAN-07-2124. PMID 17909035.

[pmid14627703-7] Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.

[pmid12917339-8] Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/mcb.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

[pmid8797824-9] Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J (Sep 1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C". Cell. 86 (5): 777–86. doi:10.1016/s0092-8674(00)80152-x. PMID 8797824. S2CID 15675524.

[pmid15090548-10] Xie J, Guo Q (Jul 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane". The Journal of Biological Chemistry. 279 (27): 28266–75. doi:10.1074/jbc.M401495200. PMID 15090548.

[pmid12717420-11] Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP (Apr 2003). "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies". Oncogene. 22 (16): 2432–42. doi:10.1038/sj.onc.1206271. PMID 12717420.

[pmid8943350-12] Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, Haber DA, Licht JD, Sugrue SP, Roberts T, Rangnekar VM, Shi Y (Dec 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Molecular and Cellular Biology. 16 (12): 6945–56. doi:10.1128/mcb.16.12.6945. PMC 231698. PMID 8943350.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

Search

PAWR

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보