농축성 뉴클레오시드 트랜스포터 2

SLC28A2
식별자
에일리어스	SLC28A2, CNT2, HCNT2, HsT17153, SPNT1, 농축뉴클레오시드 트랜스포터2, 용질담체족 28멤버 2
외부 ID	OMIM: 606208 MGI: 1913105 HomoloGene: 20891 GenCard: SLC28A2
유전자 위치(인간)
크르.	15번 염색체(인간)
끝.	45,277,846 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	122,461,137 bp
RNA발현패턴
	상단 표시 위치:
	제주날 점막; ; 십이지장; ; 직장; ; 담낭; ; 상부 신경; ; 배; ; 안저; ; 위체; ; 태반; ; 기관지 상피 세포;
	상단 표시 위치:
	jejunum; ; 십이지장; ; 회장; ; 비장; ; 흉선; ; 대퇴 사두근; ; 결장; ; 근육 조직; ; 노른자낭; ; 골격근 조직;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	푸린뉴클레오시드전달체활성; 뉴클레오시드경막수송체활성; 뉴클레오시드: 심포터 액티비티 확인;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 막; 혈장막의 적분 성분;
생물학적 과정	푸린뉴클레오시드경막수송; 뉴클레오시드경막수송; 핵산가수분해효소함유복합체;
	출처:아미고 / QuickGO
맞춤법
	9153
	269346
	ENSG00000137860
	ENSMUSG000027219
	O43868
	O88627
	NM_004212
	NM_172980; NM_001356532
	NP_004203
	NP_766568; NP_001343461; NP_001366388; NP_001366389
	위키데이터
인간 보기/편집	마우스 표시/편집

농축성 뉴클레오시드 트랜스포터 2(CNT2)는 SLC28A2 ^[5]^[6]유전자에 의해 인간에게 암호화되는 단백질이다.

「」를 참조해 주세요.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000137860 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027219 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization". Am J Physiol. 273 (6 Pt 2): F1058-65. doi:10.1152/ajprenal.1997.273.6.F1058. PMID 9435697.
^ "Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2".

추가 정보

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507.
Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109.
Pennycooke M, Chaudary N, Shuralyova I, et al. (2001). "Differential expression of human nucleoside transporters in normal and tumor tissue". Biochem. Biophys. Res. Commun. 280 (3): 951–9. doi:10.1006/bbrc.2000.4205. PMID 11162617.
Li JY, Boado RJ, Pardridge WM (2001). "Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier". J. Pharmacol. Exp. Ther. 299 (2): 735–40. PMID 11602688.
Gerstin KM, Dresser MJ, Giacomini KM (2002). "Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT". Am. J. Physiol. Renal Physiol. 283 (2): F344–9. doi:10.1152/ajprenal.00274.2001. PMID 12110519. S2CID 21332585.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin HC, Landowski CP, Sun D, et al. (2003). "Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum". Biochem. Biophys. Res. Commun. 307 (3): 696–703. doi:10.1016/S0006-291X(03)01259-2. PMID 12893280.
Lang TT, Young JD, Cass CE (2004). "Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line". Mol. Pharmacol. 65 (4): 925–33. doi:10.1124/mol.65.4.925. PMID 15044622. S2CID 5665725.
Damaraju VL, Visser F, Zhang J, et al. (2005). "Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside". Mol. Pharmacol. 67 (1): 273–9. doi:10.1124/mol.104.004408. PMID 15486050. S2CID 3017992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Owen RP, Gray JH, Taylor TR, et al. (2005). "Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2". Pharmacogenet. Genomics. 15 (2): 83–90. doi:10.1097/01213011-200502000-00004. PMID 15861032. S2CID 12817964.
Owen RP, Badagnani I, Giacomini KM (2006). "Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2". J. Biol. Chem. 281 (36): 26675–82. doi:10.1074/jbc.M513421200. PMID 16840788.
Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. S2CID 20779608.
Hirsh AJ, Stonebraker JR, van Heusden CA, et al. (2007). "Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases". Biochemistry. 46 (36): 10373–83. doi:10.1021/bi7009647. PMID 17696452.
Li L, Tan CM, Koo SH, et al. (2007). "Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians". Pharmacogenet. Genomics. 17 (9): 783–6. doi:10.1097/FPC.0b013e3281c10e41. PMID 17700367.

이 막단백질 관련 물품은 그루브입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000137860 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000027219 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9435697-5] Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization". Am J Physiol. 273 (6 Pt 2): F1058-65. doi:10.1152/ajprenal.1997.273.6.F1058. PMID 9435697.

[entrez-6] "Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2".

[1]

[2]

[3]

[4]

[5]

[6]

Search

농축성 뉴클레오시드 트랜스포터 2

네임스페이스

더

「」를 참조해 주세요.

레퍼런스

추가 정보

Search

농축성 뉴클레오시드 트랜스포터 2

「 」를 참조해 주세요.

레퍼런스

추가 정보

「」를 참조해 주세요.