음이온교환단백질2

SLC4A2
식별자
에일리어스	SLC4A2, AE2, BND3L, EPB3L1, HKB3, NBND3, 용질 캐리어 패밀리 4 멤버 2
외부 ID	OMIM: 109280 MGI: 109351 HomoloGene: 128699 GenCard: SLC4A2
유전자 위치(인간)
크르.	7번 염색체(인간)
끝.	151,076,526 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	24,645,948 bp
RNA발현패턴
	상단 표시 위치:
	위체; ; 자궁경관; ; 간우엽; ; 췌장체; ; 자궁내막간질세포; ; 좌측 자궁관; ; 망막 색소 상피; ; 좌폐 상엽; ; 우측 자궁관; ; 상행 대동맥;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	효소결합; 음이온막전달체활성; 항산화제 활성; 음이온: 음이온 안티포터 액티비티; 수송체 활성; 무기 음이온 교환기 활성; 나트륨: 중탄산 심포터 활성;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 기저측 혈장막; 꼭대기 플라즈마막; 막; 국소 접착; 혈장막의 적분 성분;
생물학적 과정	소화관 발달; 음이온 수송; 정자 형성; 이온 수송; 세포내 pH조절; 무기 음이온 수송; 막 통과 수송; 음이온막 통과 수송; 중탄산 수송; 나트륨 이온 막 통과 수송; 운송;
	출처:아미고 / QuickGO
맞춤법
	6522
	20535
	ENSG00000164889
	ENSMUSG000028962
	P04920
	P13808
	NM_001199692; NM_001199693; NM_001199694; NM_003040
	NM_001253892; NM_009207
	NP_001186621; NP_001186622; NP_001186623; NP_003031
	NP_001240821; NP_033233
	위키데이터
인간 보기/편집	마우스 표시/편집

음이온교환단백질2(AE2)는 SLC4A2 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 막수송단백질이다.AE2는 기능적으로 Band 3 Cl⁻/HCO3⁻ 교환 단백질과 유사합니다.

마우스는 AE2의 기능을 탐색하는 데 사용되었습니다.AE2는 소화관에서 ^[7]기저막 HCO₃⁻ 수송에 기여한다.AE2는 ^[8]생쥐의 정자 형성에 필요하다.AE2는 정상적인 골세포 ^[9]^[10]기능을 위해 필요합니다.AE2의 활동은 pH에 ^[11]민감합니다.

AE3는 당뇨병 혈관병증의 ^[12]예방 대상으로 제안되어 왔다.

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용질 캐리어 패밀리

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000164889 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028962 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.
^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.
^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. Bibcode:2003PNAS..10015847M. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.
^ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. Bibcode:2008PNAS..10516934W. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.
^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.
^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.
^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022. S2CID 25917589.

추가 정보

Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney". Biochim. Biophys. Acta. 1130 (3): 326–8. doi:10.1016/0167-4781(92)90446-7. PMID 1562608.
Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3". J. Biol. Chem. 263 (21): 10212–8. doi:10.1016/S0021-9258(19)81500-4. PMID 2968981.
Demuth DR, Showe LC, Ballantine M, et al. (1986). "Cloning and structural characterization of a human non-erythroid band 3-like protein". EMBO J. 5 (6): 1205–14. doi:10.1002/j.1460-2075.1986.tb04348.x. PMC 1166929. PMID 3015590.
Palumbo AP, Isobe M, Huebner K, et al. (1986). "Chromosomal localization of a human band 3-like gene to region 7q35----7q36". Am. J. Hum. Genet. 39 (3): 307–16. PMC 1683956. PMID 3020980.
Rybicki AC, Musto S, Schwartz RS (1995). "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2". Biochem. J. 309. ( Pt 2) (2): 677–81. doi:10.1042/bj3090677. PMC 1135783. PMID 7626035.
Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ (1995). "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0". Brain Res. Mol. Brain Res. 25 (1–2): 97–104. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Medina JF, Acín A, Prieto J (1997). "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene". Genomics. 39 (1): 74–85. doi:10.1006/geno.1996.4467. PMID 9027488.
García C, Montuenga LM, Medina JF, Prieto J (1998). "In situ detection of AE2 anion-exchanger mRNA in the human liver". Cell Tissue Res. 291 (3): 481–8. doi:10.1007/s004410051017. hdl:10171/20151. PMID 9477304. S2CID 22738717.
Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells". Eur. J. Cell Biol. 75 (3): 232–6. doi:10.1016/s0171-9335(98)80117-9. PMID 9587054.
Mobasheri A, Golding S, Pagakis SN, et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823. S2CID 12201584.
Hyde K, Harrison D, Hollingsworth MA, Harris A (1999). "Chloride-bicarbonate exchangers in the human fetal pancreas". Biochem. Biophys. Res. Commun. 263 (2): 315–21. doi:10.1006/bbrc.1999.1367. PMID 10491290.
Holappa K, Mustonen M, Parvinen M, et al. (1999). "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis". Biol. Reprod. 61 (4): 981–6. doi:10.1095/biolreprod61.4.981. PMID 10491633.
Karet FE, Finberg KE, Nayir A, et al. (2000). "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34". Am. J. Hum. Genet. 65 (6): 1656–65. doi:10.1086/302679. PMC 1288376. PMID 10577919.
Medina JF, Lecanda J, Acín A, et al. (2000). "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene". Biochem. Biophys. Res. Commun. 267 (1): 228–35. doi:10.1006/bbrc.1999.1951. PMID 10623603.
Vince JW, Reithmeier RA (2000). "Identification of the Carbonic Anhydrase II Binding Site in the Cl⁻/HCO₃⁻ Anion Exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
Holappa K, Suokas M, Soininen P, Kellokumpu S (2001). "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts". J. Histochem. Cytochem. 49 (2): 259–69. doi:10.1177/002215540104900213. PMID 11156694.
Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl⁻/OH⁻/HCO³⁻ exchanger in the kidney cortex". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. doi:10.1152/ajprenal.2001.280.2.f356. PMID 11208611.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

이 막단백질 관련 물품은 그루브입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000164889 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000028962 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8434259-5] Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.

[entrez-6] "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".

[pmid20110461-7] Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.

[pmid14673081-8] Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. Bibcode:2003PNAS..10015847M. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.

[pmid18971331-9] Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. Bibcode:2008PNAS..10516934W. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.

[pmid19164575-10] Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.

[pmid19103596-11] Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.

[pmid20180022-12] Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022. S2CID 25917589.

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