A-967079

A-967079
A-967079
A-967079 Structure.svg
식별자
  • (1E,3E)-1-(4-플루오로페닐)-2-메틸-1-펜텐-3-원옥심
CAS 번호
PubChem CID
켐스파이더
유니
첸블
화학 및 물리 데이터
공식C12H14FNO
몰 질량207.248 g/120−1
3D 모델(JSmol)
  • CC/C(=N/O)/C(=C/C1=CC=C(C=C1)F)/C
  • InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12H
  • 키: HKROEBDHKMNBZ-BYKJOZEVSA-N

A-967079는 TRPA1 수용체에 대한 강력하고 선택적인 길항제 역할을 하는 약물이다.진통제, 항염증 효과가 있어 과학 연구에 사용되고 있지만 [1][2][3][4][5]의학용으로 개발된 것은 아닙니다.

레퍼런스

  1. ^ Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, et al. (May 2011). "Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation". Pain. 152 (5): 1165–72. doi:10.1016/j.pain.2011.01.049. PMID 21402443. S2CID 21881155.
  2. ^ Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A (July 2012). "Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain". Anesthesiology. 117 (1): 137–48. doi:10.1097/ALN.0b013e31825adb0e. PMID 22588108. S2CID 287826.
  3. ^ Banzawa N, Saito S, Imagawa T, Kashio M, Takahashi K, Tominaga M, Ohta T (November 2014). "Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist". The Journal of Biological Chemistry. 289 (46): 31927–39. doi:10.1074/jbc.M114.586891. PMC 4231671. PMID 25271161.
  4. ^ Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014). "TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology. 114 (1): 50–5. doi:10.1111/bcpt.12138. PMID 24102997.
  5. ^ Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE (September 2018). "TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters. 293: 140–148. doi:10.1016/j.toxlet.2018.03.007. PMC 5975083. PMID 29535050.
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