GSK1702934a

GSK1702934
GSK1702934a
GSK1702934A structure.png
식별자
  • 3-[1-(5,6,7,8-테트라히드로-4H-시클로헵타[b]티오펜-2-카르보닐)피페리딘-4-일]-1H-벤즈이미다졸-2-온
CAS 번호
PubChem CID
켐스파이더
화학 및 물리 데이터
공식C22H25N3O2S
몰 질량395.52 g/g−1/g/g
3D 모델(JSmol)
  • C1CC2=C(CC1)SC(=C2)C(=O)N3CC(CC3)N4C5=CC=CC=C5NC4=O
  • InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-3-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(1823-277)
  • 키: AXWRAIIIBRLXBP-UHFFFAOYSA-N

GSK1702934ATRPC3TRPC6 서브타입에 대한 선택성을 가진 칼슘 채널의 TRPC 패밀리의 활성제 역할을 하는 화합물이다.그것은 [1][2][3][4]뇌에서의 역할뿐만 아니라 심장 기능과 혈압 조절에서 TRPC 채널의 역할을 조사하는데 사용되어 왔다.

레퍼런스

  1. ^ Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg (2013). "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104: 454a. doi:10.1016/j.bpj.2012.11.2513.
  2. ^ Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K (April 2015). "TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1". Cardiovascular Research. 106 (1): 163–73. doi:10.1093/cvr/cvv022. PMC 4362401. PMID 25631581.
  3. ^ Tiapko O, Groschner K (July 2018). "TRPC3 as a Target of Novel Therapeutic Interventions". Cells. 7 (7). doi:10.3390/cells7070083. PMC 6071100. PMID 30037143.
  4. ^ Wang Y, Liu L, Tao H, Wen L, Qin S (December 2020). "TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats". Heart and Vessels. 35 (12): 1755–1765. doi:10.1007/s00380-020-01682-1. PMID 32844288.