ACP-105
ACP-105법적 상태 | |
---|---|
법적 상태 |
|
식별자 | |
| |
CAS 번호 | |
PubChem CID | |
켐스파이더 | |
첸블 | |
화학 및 물리 데이터 | |
공식 | C16H19클론N2O |
몰 질량 | 290.79g/표준−1 |
3D 모델(JSmol) | |
| |
|
ACP-105는 선택적 안드로겐 수용체 변조기(SARM) 역할을 하는 약물로 노화에 따른 인지력 [1][2][3][4]저하 치료에 대해 연구되어 왔다.
「 」를 참조해 주세요.
레퍼런스
- ^ Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, et al. (November 2009). "Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators". Journal of Medicinal Chemistry. 52 (22): 7186–7191. doi:10.1021/jm901149c. PMID 19856921.
- ^ Dayger C, Villasana L, Pfankuch T, Davis M, Raber J (March 2011). "Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice". Brain Research. 1381: 134–140. doi:10.1016/j.brainres.2010.12.088. PMC 3048897. PMID 21219889.
- ^ George S, Petit GH, Gouras GK, Brundin P, Olsson R (December 2013). "Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease". ACS Chemical Neuroscience. 4 (12): 1537–1548. doi:10.1021/cn400133s. PMC 3867967. PMID 24020966.
- ^ Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021). "Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes". Drug Testing and Analysis. doi:10.1002/dta.3189. PMID 34714606. S2CID 240152623.