이노시톨 1,4, 5-트리스인산 수용체 타입 3은 ITPR3 유전자 에 의해 인코딩되는 단백질 이다. [5] 이 유전자에 의해 암호화된 단백질 은 이노시톨 삼인산 수용체 와 칼슘 통로 둘 다이다.[6]
함수 ITP3 채널은 단맛 , 쓴맛 , 우마미 의 맛 전도에 중요 한 역할을 한다. ITP3 채널은 IP3에 대응하여 소포체 망막 밖으로 칼슘의 흐름을 허용한다. 칼슘 양이온으로 인해 TRPM5가 활성화되어 탈분극화 발생 잠재력과 작용 잠재력을 갖게 된다.[7]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000096433 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000042644 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: inositol 1" .^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels . 2 (1): 9–22. PMID 8081734 . ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste" . J. Cell Biol . 190 (3): 285–96. doi :10.1083/jcb.201003144 . PMC 2922655 PMID 20696704 . 추가 읽기 Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor" . J. Cell. Biochem . 104 (4): 1244–53. doi :10.1002/jcb.21704 . 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"Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling" . J. Biol. Chem . 279 (12): 11967–75. doi :10.1074/jbc.M311456200 PMID 14707143 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden" . Am. J. Hum. Genet . 79 (4): 614–27. doi :10.1086/507876 . PMC 1592562 PMID 16960798 . Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca2+ store" . J. Pharmacol. Sci . 107 (2): 138–50. doi :10.1254/jphs.08021FP PMID 18544901 . Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res . 295 (1): 102–18. doi :10.1016/j.yexcr.2003.12.025 . PMID 15051494 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection" . J. Neurosci . 28 (17): 4293–4. doi :10.1523/JNEUROSCI.0644-08.2008 PMC 6670947 PMID 18434505 . Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II" . Genes Immun . 9 (3): 264–6. doi :10.1038/gene.2008.12 PMID 18340361 . Wu Z, Bowen WD (2008). 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