인간 내 단백질 부호화 유전자
칼륨 채널 서브 패밀리 K 멤버 6 은 인간에서 KCNK6 유전자 에 의해 인코딩 되는 단백질이다.[5] [6] [7] [8]
이 유전자는 두 개의 모공 형성 P 도메인을 포함하는 칼륨 채널 단백질의 슈퍼 패밀리의 하나인 K62P .1 을 암호화하고 있다. 개방형 정류기로 간주되는 K62P .1은 널리 표현되어 있다. 아라키돈산에 의해 자극을 받고, 내산화와 휘발성 마취에 의해 억제된다.[8]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000099337 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000046410 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family" . J Biol Chem . 274 (12): 7887–92. doi :10.1074/jbc.274.12.7887 PMID 10075682 . ^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet . 84 (3–4): 190–1. doi :10.1159/000015255 . PMID 10393428 . S2CID 84538070 . ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels" . Pharmacol Rev . 57 (4): 527–40. doi :10.1124/pr.57.4.12 . PMID 16382106 . S2CID 7356601 . ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6" .
추가 읽기 Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nat. Rev. Neurosci . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 . Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management". Gastrointestinal Radiology . 1 (2): 167–71. doi :10.1007/BF02256360 . PMID 1088718 . S2CID 12318832 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure" . J. Biol. Chem . 274 (17): 11751–60. doi :10.1074/jbc.274.17.11751 PMID 10206991 . Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit" . FEBS Lett . 450 (3): 191–6. doi :10.1016/S0014-5793(99)00495-0 PMID 10359073 . S2CID 42980921 . Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel" . J. Biol. Chem . 275 (37): 28722–30. doi :10.1074/jbc.M003755200 PMID 10887187 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4". J. Neurosci. Res . 75 (1): 25–31. doi :10.1002/jnr.10839 . PMID 14689445 . S2CID 19133204 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 외부 링크 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
