ITPR2

ITPR2
식별자
별칭	ITPR2, CFAP48, IP3R2, ANHD, INS3R2, 이노시톨 1,4,5-트리스포스산 수용체 유형 2
외부 ID	OMIM: 600144 MGI: 99418 HomoloGene: 37593 GeneCard: ITPR2
유전자 위치(인간)
쳇.	12번 염색체(인간)
끝	26,833,192 bp
유전자 위치(마우스)
쳇.	6번 염색체(쥐)
끝	146,403,721 bp
RNA 표현 패턴
	표현된 상단
	간; ; 말뭉치 담낭; ; 아킬레스건; ; 뱃속; ; 폐를 끼치다; ; 결장의; ; 침샘;
	추가 참조 표현식 데이터
	n/a
유전자 온톨로지
분자함수	칼슘 통로 활동; 칼슘 방출 채널 활동; 칼슘 이온 투과형 트랜스포터 활동; 이온 채널 활성; 칼슘 이온 결합; 인산염리노시톨 결합; 이노시톨 1,4,5-트리스포스포산염 민감 칼슘 방출 채널 활성; 비계단백질결합; 이노시톨 1,4,5 삼인산 결합;
셀룰러 컴포넌트	세포질; 막의 적분 성분; 소포체 망막; 막으로 막다; 수용체 복합체; 플라즈마 막; 사관절개망막; 세포피질; 혈소판 밀도 관망막; 사구경 망막; 핵의; 소포체성 망막; 세포질 방광막; 비료 과립막;
생물학적 과정	심전도 조절; 저산소증에 대한 반응; 에탄올에 대한 세포 반응; 인슐린 분비의 조절; 이온 수송; 혈소판 활성화; 칼슘 이온 투과탄 수송; 트랜스엠브레인 수송; 이노시톨 인산염 매개 신호; cAMP에 대한 세포 반응; 신호 전달; 칼슘 이온 수송; 격리된 칼슘 이온을 시토솔로 방출; 운송;
	출처:아미고 / 퀵고
직교체
	3709
	16439
	ENSG00000123104
	ENSMUSG00000030287
	Q14571
	Q9Z329
	NM_002223
	NM_010586; NM_019923
	NP_002214
	NP_034716; NP_064307
	위키다타
인간 보기/편집	마우스 보기/편집

ITPR2라고도 알려진 이노시톨 1,4,5-트리스인산 수용체 타입 2는 인간에서 ITPR2 유전자에 의해 인코딩되는 단백질이다.^[5]이 유전자에 의해 암호화된 단백질은 이노시톨 삼인산 수용체와 칼슘 통로 둘 다이다.^[6]

참고 항목

이노시톨 트리스인산 수용체

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000123104 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000030287 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: inositol 1".
^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.

추가 읽기

Jardín I, Lápez JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets". Cell. Signal. 20 (4): 737–47. doi:10.1016/j.cellsig.2007.12.010. PMID 18249094.
Wilker E, Mittleman MA, Litonjua AA, et al. (2009). "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter". Environ. Health Perspect. 117 (6): 935–40. doi:10.1289/ehp.0800279. PMC 2702409. PMID 19590686.
Rosado JA, Sage SO (2001). "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets". Biochem. J. 356 (Pt 1): 191–8. doi:10.1042/0264-6021:3560191. PMC 1221827. PMID 11336651.
van Es MA, Van Vught PW, Blauw HM, et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study". Lancet Neurology. 6 (10): 869–77. doi:10.1016/S1474-4422(07)70222-3. PMID 17827064. S2CID 12953367.
Harzheim D, Movassagh M, Foo RS, et al. (2009). "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. Bibcode:2009PNAS..10611406H. doi:10.1073/pnas.0905485106. PMC 2708695. PMID 19549843.
Rosado JA, Sage SO (2000). "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted". Biochem. J. 350 Pt 3 (3): 631–5. doi:10.1042/0264-6021:3500631. PMC 1221291. PMID 10970773.
Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
Chiò A, Schymick JC, Restagno G, et al. (2009). "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis". Hum. Mol. Genet. 18 (8): 1524–32. doi:10.1093/hmg/ddp059. PMC 2664150. PMID 19193627.
Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol. 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169. S2CID 36516047.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mery L, Magnino F, Schmidt K, et al. (2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Lett. 487 (3): 377–83. doi:10.1016/S0014-5793(00)02362-0. PMID 11163362. S2CID 44945442.
Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells". Cell Calcium. 27 (6): 315–28. doi:10.1054/ceca.2000.0126. PMID 11013462.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.
Jurkovicova D, Sedlakova B, Lacinova L, et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line". Ann. N. Y. Acad. Sci. 1148 (1): 421–7. Bibcode:2008NYASA1148..421J. doi:10.1196/annals.1410.034. PMID 19120137. S2CID 19136722.
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling". J. Biol. Chem. 277 (2): 1340–8. doi:10.1074/jbc.M106609200. PMID 11694504.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tovey SC, Dedos SG, Taylor EJ, et al. (2008). "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP". J. Cell Biol. 183 (2): 297–311. doi:10.1083/jcb.200803172. PMC 2568025. PMID 18936250.
Johnson JM, Castle J, Garrett-Engele P, et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. Bibcode:2003Sci...302.2141J. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.

외부 링크

ITPR2+단백질,+인간, 미국 국립 의학 도서관 의료 과목 제목(MesH)

이 막 단백질 관련 기사는 뭉툭하다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000123104 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000030287 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: inositol 1".

[pmid8081734-6] Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734.

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ITPR2

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