사벨루졸
Sabeluzole임상자료 | |
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ATC 코드 |
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법적현황 | |
법적현황 |
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식별자 | |
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CAS 번호 | |
펍켐 CID | |
켐스파이더 | |
유니 | |
화학 및 물리적 데이터 | |
공식 | C22H26FN3O2S |
어금질량 | 415.53 g·1998−1 |
3D 모델(JSmol) | |
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(iii) |
사벨루졸(R-58,735)은 원래 알츠하이머병 치료를 위해 개발된 불순방성 신경보호제로서,[1][2] 이후 수면아프노아 등 다른 용도에 대해 연구되어 왔다.[3] 그것은 주로 NMDA 대항마로 작용하지만,[4] 다른 행동 메커니즘도 중요할 수 있다.[5][6]
참고 항목
참조
- ^ Clincke GH, Tritsmans L, Idzikowski C, Amery WK, Janssen PA (1988). "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology. 94 (1): 52–7. doi:10.1007/BF00735880. PMID 3126527. S2CID 28451054.
- ^ Mohr E, Nair NP, Sampson M, Murtha S, Belanger G, Pappas B, Mendis T (August 1997). "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology. 20 (4): 338–45. doi:10.1097/00002826-199708000-00005. PMID 9260731.
- ^ Hedner J, Grunstein R, Eriksson B, Ejnell H (May 1996). "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep. 19 (4): 287–9. doi:10.1093/sleep/19.4.287. PMID 8776785.
- ^ Van der Valk JB, Vijverberg HP (February 1993). "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology. 232 (1): 131–4. doi:10.1016/0014-2999(93)90738-4. PMID 8458392.
- ^ Geerts H, Nuydens R, De Jong M, Cornelissen F, Nuyens R, Wouters L (1996). "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging. 17 (4): 573–81. doi:10.1016/0197-4580(96)00067-x. PMID 8832632. S2CID 25920662.
- ^ Uberti D, Rizzini C, Galli P, Pizzi M, Grilli M, Lesage A, et al. (June 1997). "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death" (PDF). Synapse. 26 (2): 95–103. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. hdl:11379/164175. PMID 9131769.