흥분성 아미노산 운반체 1
Excitatory amino acid transporter 1| SLC1A3 | |||||||||||||||||||||||||
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| 에일리어스 | SLC1A3, EA6, EAAT1, GLAST, GLAST1, 용질 캐리어 패밀리1 멤버 3 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 600111 MGI: 99917 HomoloGene: 20882 GenCard: SLC1A3 | ||||||||||||||||||||||||
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| 맞춤법 | |||||||||||||||||||||||||
| 종. | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 장소(UCSC) | Chr 5: 36.6 ~36.69 Mb | Chr 15: 8.66 ~8.74 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
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흥분성 아미노산 트랜스포터 1(EAAT1)은 SLC1A3 [5]유전자에 의해 인간 내에서 암호화되는 단백질이다.EAAT1은 GLutamate ASpartate Transporter 1(GLAST-1)이라고도 불립니다.
EAAT1은 주로 혈장막에서 발현되어 세포외 [6]공간에서 글루탐산염을 제거할 수 있다.그것은 또한 말산 아스파르트산 [7]셔틀의 일부로 미토콘드리아 내막에서 국부화 되었다.
메커니즘
EAAT1은 생체 내에서 호모트리머로 [8]기능한다.EAAT1은 글루탐산 및 아스파라긴산 수송을 3Na+ 및 1H+ 양이온의 공수송과 1K+ 양이온의 역수송을 매개한다.이 공수송 커플링(또는 심포트)은 농도 [9]구배에 대한 글루탐산염의 세포로의 이동을 가능하게 한다.
"말레이트-아스파르트산 셔틀 경로를 나타내는 다이어그램" (중앙 하단에 표시된 글루탐산 아스파르트산 수송체)
베르그만 글리아 섬유 중 SLC1A3의 발현.생후 7일째, 시상부 생쥐 뇌, GENSAT 데이터베이스.
조직 분포
EAAT1은 CNS [10]전체에서 발현되며, 소뇌의 [11][12]성세포 및 베르그만 글리아에서 고도로 발현된다.망막에서 [13]EAAT1은 뮬러 세포에서 발현된다.EAAT1은 또한 심장근구를 [7]포함한 많은 다른 조직에서도 발현된다.
임상적 의의
그것은 6타입의 일시적인 운동실조와 [14]관련이 있다.EAAT1 발현도 골관절염과 [15]연관될 수 있다.
약리학
DL-트레오-베타-벤질옥시아스파르트산(TBOA)은 흥분성 아미노산 수송체의 [16]억제제이다.
2-아미노-5-옥소-5, 6, 7, 8-테트라히드로-4H-크로멘-3-카르보니트릴의 [17]4위 및 7위치의 25개 치환 조합에 기초한 EAAT1의 선택적 억제제가 최근 발견되었다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000079215 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005360 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3".
- ^ Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC (March 1995). "Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations". The Journal of Neuroscience. 15 (3 Pt 1): 1835–53. doi:10.1523/JNEUROSCI.15-03-01835.1995. PMC 6578153. PMID 7891138.
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- ^ Gendreau S, Voswinkel S, Torres-Salazar D, Lang N, Heidtmann H, Detro-Dassen S, Schmalzing G, Hidalgo P, Fahlke C (September 2004). "A trimeric quaternary structure is conserved in bacterial and human glutamate transporters". The Journal of Biological Chemistry. 279 (38): 39505–12. doi:10.1074/jbc.M408038200. PMID 15265858. S2CID 16077315.
- ^ Kanai Y, Hediger MA (February 2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflügers Archiv. 447 (5): 469–79. doi:10.1007/s00424-003-1146-4. PMID 14530974. S2CID 21564906.
- ^ Danbolt NC (September 2001). "Glutamate uptake". Progress in Neurobiology. 65 (1): 1–105. doi:10.1016/S0301-0082(00)00067-8. PMID 11369436. S2CID 27347413.
- ^ Storck T, Schulte S, Hofmann K, Stoffel W (November 1992). "Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain". Proceedings of the National Academy of Sciences of the United States of America. 89 (22): 10955–9. Bibcode:1992PNAS...8910955S. doi:10.1073/pnas.89.22.10955. PMC 50461. PMID 1279699.
- ^ Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW (September 1994). "Localization of neuronal and glial glutamate transporters". Neuron. 13 (3): 713–25. doi:10.1016/0896-6273(94)90038-8. PMID 7917301. S2CID 45299639.
- ^ Rauen T, Taylor WR, Kuhlbrodt K, Wiessner M (January 1998). "High-affinity glutamate transporters in the rat retina: a major role of the glial glutamate transporter GLAST-1 in transmitter clearance". Cell and Tissue Research. 291 (1): 19–31. doi:10.1007/s004410050976. PMID 9394040. S2CID 6814592.
- ^ Jen JC, Wan J, Palos TP, Howard BD, Baloh RW (August 2005). "Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures". Neurology. 65 (4): 529–34. doi:10.1212/01.WNL.0000172638.58172.5a. PMID 16116111. S2CID 22492395.
- ^ Mason DJ, Brakspear K, Wilson C, Williams R, Kotwal RS (July 2010). "Expression of glutamate receptors and transporters in human subchondral bone in osteoarthritis". Orthopaedic Proceedings. The British Editorial Society of Bone & Joint Surgery. 93-B (SUPP_I): 411. doi:10.1302/0301-620X.93BSUPP_I.0930069b (inactive 28 February 2022).
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- ^ Jensen AA, Erichsen MN, Nielsen CW, Stensbøl TB, Kehler J, Bunch L (February 2009). "Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1". Journal of Medicinal Chemistry. 52 (4): 912–5. doi:10.1021/jm8013458. PMID 19161278.
추가 정보
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