케라틴 18

KRT18
식별자
별칭	KRT18, CK-18, CYK18, K18, 케라틴 18
외부 ID	OMIM: 148070 MGI: 96692 HomoloGene: 55448 GeneCard: KRT18
유전자 위치(인간)
쳇.	12번 염색체(인간)
끝	52,952,906 bp
유전자 위치(마우스)
쳇.	15번 염색체(쥐)
끝	102,032,027 bp
RNA 표현 패턴
	표현된 상단
	전방 뇌하수체; ; 뇌하수체; ; 근육 조직; ; 랑게르한스 섬; ; 좌측 폐 상부엽; ; 췌장체; ; 직장의;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	비계단백질결합; 구조 분자 활성; GO:0001948 단백질 결합; 세포-세포 접착에 관련된 캐더린 결합; RNA 결합;
셀룰러 컴포넌트	세포질; 구면 위성; 각질 필라멘트; 미세관 조직 센터; 뉴클레오루스; 세포질 과핵 지역; 세포외 외성체; 중간 필라멘트; 세포 주변부; 핵의; 시토솔;
생물학적 과정	골지와 혈장막 CFTR 단백질 이송; 세포외 신호 경로; 해부학적 구조 형태발생; 세포핵 과정에 대한 부정적인 규제; 종양 괴사 인자 매개 신호 경로; 중간 필라멘트 사이토스켈레톤 조직; 세포 순환; GO:0022415 바이러스 처리; 간세포 세포사멸 과정; 세포-세포 접착; 각질화; 옥수수화;
	출처:아미고 / 퀵고
직교체
	3875
	16668
	ENSG00000111057
	ENSMUSG00000023043
	P05783
	P05784
	NM_199187; NM_000224
	NM_010664
	NP_000215; NP_954657
	NP_034794
	위키다타
인간 보기/편집	마우스 보기/편집

케라틴 18은 I형 사이토케라틴이다. 그것은 필라멘트 파트너 케라틴 8과 함께 아마도 중간 필라멘트 유전자 계열에서 가장 흔히 발견되는 제품일 것이다. 그것들은 신체의 단층 상피 조직으로 표현된다. 이 유전자의 돌연변이는 암호화된 간경변과 연관되어 있다. 이 유전자에 대해 동일한 단백질을 인코딩하는 두 개의 대본변형이 발견되었다.^[5]

케라틴 18은 혈액 내 순환 종양 세포를 열거하는 검사에서 상피 기원의 세포를 조혈세포와 구별하기 위해 케라틴 8, 케라틴 19와 함께 사용하는 경우가 많다.^[6]

상호작용

케라틴 18은 타입 XVII,^[7] 알파1, DNAJB6,^[8] 피닌^[9], TRADD와 상호작용하는 것으로 나타났다.^[10]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000111057 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000023043 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KRT18 keratin 18".
^ W. Jeffrey Allard; Jeri Matera; M. Craig Miller; et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clinical Cancer Research. 10 (20): 6897–6904. doi:10.1158/1078-0432.CCR-04-0378. PMID 15501967.
^ Aho, S; Uitto J (March 1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18". J. Cell. Biochem. 72 (3): 356–67. doi:10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M. ISSN 0730-2312. PMID 10022517.
^ Izawa, I; Nishizawa M; Ohtakara K; Ohtsuka K; Inada H; Inagaki M (November 2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. ISSN 0021-9258. PMID 10954706.
^ Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.
^ Inada, H; Izawa I; Nishizawa M; Fujita E; Kiyono T; Takahashi T; Momoi T; Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708.

추가 읽기

Omary MB, Baxter GT, Chou CF, et al. (1992). "PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18". J. Cell Biol. 117 (3): 583–93. doi:10.1083/jcb.117.3.583. PMC 2289443. PMID 1374067.
Waseem A, Gough AC, Spurr NK, Lane EB (1990). "Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction". Genomics. 7 (2): 188–94. doi:10.1016/0888-7543(90)90540-B. PMID 1693358.
Heath P, Elvin P, Jenner D, et al. (1990). "Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation". Hum. Genet. 85 (6): 669–70. doi:10.1007/BF00193596. PMID 1699878. S2CID 19296094.
Waseem A, Alexander CM, Steel JB, Lane EB (1991). "Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs". New Biol. 2 (5): 464–78. PMID 1705144.
Romano V, Hatzfeld M, Magin TM, et al. (1986). "Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone". Differentiation. 30 (3): 244–53. doi:10.1111/j.1432-0436.1986.tb00787.x. PMID 2422083.
Oshima RG, Millán JL, Ceceña G (1987). "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation". Differentiation. 33 (1): 61–8. doi:10.1111/j.1432-0436.1987.tb01542.x. PMID 2434380.
Leube RE, Bosch FX, Romano V, et al. (1987). "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ". Differentiation. 33 (1): 69–85. doi:10.1111/j.1432-0436.1986.tb00412.x. PMID 2434381.
Kulesh DA, Oshima RG (1988). "Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells". Mol. Cell. Biol. 8 (4): 1540–50. doi:10.1128/MCB.8.4.1540. PMC 363314. PMID 2454392.
Sémat A, Vasseur M, Maillet L, et al. (1988). "Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells". Differentiation. 37 (1): 40–6. doi:10.1111/j.1432-0436.1988.tb00794.x. PMID 2454862.
Kulesh DA, Oshima RG (1989). "Complete structure of the gene for human keratin 18". Genomics. 4 (3): 339–47. doi:10.1016/0888-7543(89)90340-6. PMID 2469635.
Ku NO, Omary MB (1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization". J. Cell Biol. 127 (1): 161–71. doi:10.1083/jcb.127.1.161. PMC 2120194. PMID 7523419.
Liao J, Lowthert LA, Ghori N, Omary MB (1995). "The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner". J. Biol. Chem. 270 (2): 915–22. doi:10.1074/jbc.270.2.915. PMID 7529764.
Yoon SJ, LeBlanc-Straceski J, Ward D, et al. (1995). "Organization of the human keratin type II gene cluster at 12q13". Genomics. 24 (3): 502–8. doi:10.1006/geno.1994.1659. PMID 7536183.
Ku NO, Omary MB (1995). "Identification and mutational analysis of the glycosylation sites of human keratin 18". J. Biol. Chem. 270 (20): 11820–7. doi:10.1074/jbc.270.20.11820. PMID 7538124.
Neumaier M, Gerhard M, Wagener C (1995). "Diagnosis of micrometastases by the amplification of tissue-specific genes". Gene. 159 (1): 43–7. doi:10.1016/0378-1119(94)00522-T. PMID 7541767.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Liao J, Lowthert LA, Ku NO, et al. (1996). "Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues". J. Cell Biol. 131 (5): 1291–301. doi:10.1083/jcb.131.5.1291. PMC 2120635. PMID 8522590.
Ku NO, Wright TL, Terrault NA, et al. (1997). "Mutation of human keratin 18 in association with cryptogenic cirrhosis". J. Clin. Invest. 99 (1): 19–23. doi:10.1172/JCI119127. PMC 507762. PMID 9011570.
Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis. 18 (3–4): 605–13. doi:10.1002/elps.1150180344. PMID 9150948. S2CID 25454450.

12번 염색체의 유전자에 관한 이 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000111057 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000023043 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: KRT18 keratin 18".

[6] W. Jeffrey Allard; Jeri Matera; M. Craig Miller; et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clinical Cancer Research. 10 (20): 6897–6904. doi:10.1158/1078-0432.CCR-04-0378. PMID 15501967.

[pmid10022517-7] Aho, S; Uitto J (March 1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18". J. Cell. Biochem. 72 (3): 356–67. doi:10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M. ISSN 0730-2312. PMID 10022517.

[pmid10954706-8] Izawa, I; Nishizawa M; Ohtakara K; Ohtsuka K; Inada H; Inagaki M (November 2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. ISSN 0021-9258. PMID 10954706.

[pmid10809736-9] Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.

[pmid11684708-10] Inada, H; Izawa I; Nishizawa M; Fujita E; Kiyono T; Takahashi T; Momoi T; Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708.

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케라틴 18

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