Profilin-2 는 인간에게 PFN2 유전자 에 의해 암호화된 단백질 이다.[4] [5] [6]
이 유전자에 의해 인코딩된 단백질은 프로필린 계열에 속하는 유비쿼터스 액틴 단층결합 단백질이다. 세포외 신호에 대응하여 액틴 중합성을 조절하는 것으로 생각된다. 이 유전자에 대해 기술된 서로 다른 ISO 양식을 인코딩하는 두 개의 다른 분할된 대본 변형들이 있다.[6]
상호작용 PFN2는 ROCK1 , [7] Vasodilator-stimulated phosphoprotein ,[8] [9] CCDC113 [10] FMNL1 과 상호작용 하는 것으로 나타났다.[11]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000070087 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Joensuu T, Blanco G, Pakarinen L, Sistonen P, Kaariainen H, Brown S, Chapelle A, Sankila EM (March 1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region". Genomics . 38 (3): 255–63. doi :10.1006/geno.1996.0626 . PMID 8975700 . ^ Honore B, Madsen P, Andersen AH, Leffers H (October 1993). "Cloning and expression of a novel human profilin variant, profilin II" . FEBS Lett . 330 (2): 151–5. doi :10.1016/0014-5793(93)80262-S PMID 8365484 . S2CID 46347046 . ^ a b "Entrez Gene: PFN2 profilin 2" .^ Da Silva, Jorge Santos; Medina Miguel; Zuliani Cecilia; Di Nardo Alessia; Witke Walter; Dotti Carlos G (September 2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability" . J. Cell Biol . United States. 162 (7): 1267–79. doi :10.1083/jcb.200304021 . ISSN 0021-9525 . PMC 2173969 PMID 14517206 . ^ Reinhard, M; Giehl K; Abel K; Haffner C; Jarchau T; Hoppe V; Jockusch B M; Walter U (April 1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins" . EMBO J . ENGLAND. 14 (8): 1583–9. doi :10.1002/j.1460-2075.1995.tb07146.x . ISSN 0261-4189 . PMC 398250 PMID 7737110 . ^ Harbeck, B; Hüttelmaier S; Schluter K; Jockusch B M; Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin" . J. Biol. Chem . UNITED STATES. 275 (40): 30817–25. doi :10.1074/jbc.M005066200 ISSN 0021-9258 . PMID 10882740 . ^ "Coiled-Coil Domain Containing 113" . GeneCards. Retrieved 5/8/2013 .^ Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages" . Mol. Cell. Biol . UNITED STATES. 20 (18): 6872–81. doi :10.1128/MCB.20.18.6872-6881.2000 . ISSN 0270-7306 . PMC 86228 PMID 10958683 .
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