염색체 관련 키네신 KIF4A 는 인간에서 KIF4A 유전자 에 의해 암호화된 단백질 이다.[1] [2]
KIF4A 재단 은 KIF4A 관련 증후군(KAS)으로 피해를 입은 가족을 연결하고 치료법을 찾기 위한 연구를 가속화하는 데 헌신하는 비영리 단체다. 자세한 내용은 KIF4A.org 을 참조하십시오.
함수 KIF4A와 같은 키네신은 미세관(microtubule ) 기반의 운동 단백질로 미세관(microtubule)을 따라 방향 운동을 일으킨다. 그들은 세포 분열을 포함한 많은 중요한 세포 과정에 관여한다.[2]
상호작용 KIF4A는 HMG20B [7] DNMT3B 와 상호작용 하는 것으로 나타났다.[8]
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"Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation" . The EMBO Journal . 23 (16): 3237–48. doi :10.1038/sj.emboj.7600347 . PMC 514520 PMID 15297875 . Mazumdar M, Sundareshan S, Misteli T (Aug 2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation" . The Journal of Cell Biology . 166 (5): 613–20. doi :10.1083/jcb.200401142 . PMC 2172419 PMID 15326200 . Zhu C, Jiang W (Jan 2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis" . Proceedings of the National Academy of Sciences of the United States of America . 102 (2): 343–8. Bibcode :2005PNAS..102..343Z . doi :10.1073/pnas.0408438102 PMC 544298 PMID 15625105 . 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