MYO6 라고도 알려진 미오신 6세 는 단백질 이다. 인간, 쥐, 초파리(드로소필라 멜라노가스터 선충류 케노하브디트염
함수 미오신 6세는 세포내 베시클과 오르가넬 수송에 관여하는 분자 운동이다. 이른바 파격적인 마이오신 중 하나이다. [OMIM에 의해 제공][5]
상호작용 MYO6는 GIPC1 ,[6] [7] DAB2 ,[8] [9] 유비쿼티틴 [10] 클래트린 과[11] 상호 작용하는 것으로 나타났다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000196586 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000033577 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: MYO6 myosin VI" .^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . ^ Sennacherib L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries" . Molecular Biology of the Cell . 14 (7): 2728–43. doi :10.1091/mbc.E02-11-0767 . PMC 165672 PMID 12857860 . ^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic . 3 (5): 331–41. doi :10.1034/j.1600-0854.2002.30503.x . PMID 11967127 . S2CID 25079713 . ^ Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications . 292 (2): 300–7. doi :10.1006/bbrc.2002.6636 . PMID 11906161 . ^ He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ (2016). "Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains" . Cell Reports . 14 (11): 2683–94. doi :10.1016/j.celrep.2016.01.079 . PMC 4805485 PMID 26971995 . ^ Biancospino M, Buel GR, Niño CA, Maspero E, di Perrotolo RS, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S (2019). "Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension" . Nature Communications . 10 (1): 4974. Bibcode :2019NatCo..10.4974B . doi :10.1038/s41467-019-12855-6 . PMC 6823378 PMID 31672988 . 추가 읽기 Buss F, Luzio JP, Kendrick-Jones J (Nov 2001). "Myosin VI, a new force in clathrin mediated endocytosis" . FEBS Letters . 508 (3): 295–9. doi :10.1016/S0014-5793(01)03065-4 PMID 11728438 . S2CID 44995651 . Hasson T (Sep 2003). "Myosin VI: two distinct roles in endocytosis" . Journal of Cell Science . 116 (Pt 17): 3453–61. doi :10.1242/jcs.00669 PMID 12893809 . Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (Dec 1995). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nature Genetics . 11 (4): 369–75. doi :10.1038/ng1295-369 . PMID 7493015 . S2CID 29467878 . Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types" . Proceedings of the National Academy of Sciences of the United States of America . 91 (14): 6549–53. Bibcode :1994PNAS...91.6549B . doi :10.1073/pnas.91.14.6549 PMC 44240 PMID 8022818 . Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 4 (2): 141–50. doi :10.1093/dnares/4.2.141 PMID 9205841 . Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA (Aug 1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice" . Human Molecular Genetics . 6 (8): 1225–31. doi :10.1093/hmg/6.8.1225 PMID 9259267 . Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation" . The Journal of Cell Biology . 143 (6): 1535–45. doi :10.1083/jcb.143.6.1535 . PMC 2132970 PMID 9852149 . Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (Sep 1999). "Myosin VI is an actin-based motor that moves backwards". Nature . 401 (6752): 505–8. Bibcode :1999Natur.401..505W . doi :10.1038/46835 . PMID 10519557 . S2CID 1420305 . Buss F, Arden SD, Lindsay M, Luzio JP, Kendrick-Jones J (Jul 2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis" . The EMBO Journal . 20 (14): 3676–84. doi :10.1093/emboj/20.14.3676 . PMC 125554 PMID 11447109 . Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P (Sep 2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss" . American Journal of Human Genetics . 69 (3): 635–40. doi :10.1086/323156 . PMC 1235492 PMID 11468689 . Yoshimura M, Homma K, Saito J, Inoue A, Ikebe R, Ikebe M (Oct 2001). "Dual regulation of mammalian myosin VI motor function" . The Journal of Biological Chemistry . 276 (43): 39600–7. doi :10.1074/jbc.M105080200 PMID 11517222 . Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL (Nov 2001). "Myosin VI is a processive motor with a large step size" . Proceedings of the National Academy of Sciences of the United States of America . 98 (24): 13655–9. Bibcode :2001PNAS...9813655R . doi :10.1073/pnas.191512398 PMC 61096 PMID 11707568 . Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications . 292 (2): 300–7. doi :10.1006/bbrc.2002.6636 . PMID 11906161 . Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic . 3 (5): 331–41. doi :10.1034/j.1600-0854.2002.30503.x . PMID 11967127 . S2CID 25079713 . Wu H, Nash JE, Zamorano P, Garner CC (Aug 2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking" . The Journal of Biological Chemistry . 277 (34): 30928–34. doi :10.1074/jbc.M203735200 PMID 12050163 . Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (May 2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37" . American Journal of Human Genetics . 72 (5): 1315–22. doi :10.1086/375122 . PMC 1180285 PMID 12687499 . Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries" . Molecular Biology of the Cell . 14 (7): 2728–43. doi :10.1091/mbc.E02-11-0767 . PMC 165672 PMID 12857860 .
외부 링크
PDB 갤러리
2bkh : 미오신 VI 뉴클레오타이드 프리(MDINSERT2) 크리스털 구조
2bki : 마이오신 VI 뉴클레오티드 프리(MDINSERT2-IQ) 크리스털 구조
