엔보플라킨

EVPL
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4QMD
식별자
별칭	EVPL, EVPK, Envoplakin
외부 ID	OMIM: 601590 MGI: 107507 HomoloGene: 1506 GeneCard: EVPL
유전자 위치(인간)
쳇.	17번 염색체(인간)
끝	76,027,306 bp
유전자 위치(마우스)
쳇.	11번 염색체(쥐)
끝	116,238,077 bp
RNA 표현 패턴
	표현된 상단
	식도; ; 질질 끌다; ; 잇몸;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	단백질-매크로몰리큘 어댑터 활동; 중간 필라멘트 바인딩; 구조 분자 활성; 캐더린 제본;
셀룰러 컴포넌트	세포 접합; 데스모좀; 중간 필라멘트 사이토스켈레톤; 세포외 외성체; 시토스켈레톤; 옥수수 봉투; 세포질; 시토솔; 중간 필라멘트; 막으로 막다;
생물학적 과정	펩타이드 교차 혼합물; 각질화; 각질 세포 분화; 표피 발달; 옥수수화; 상처 치유; 중간 필라멘트 사이토스켈레톤 조직;
	출처:아미고 / 퀵고
직교체
	2125
	14027
	ENSG00000167880
	ENSMUSG00000034282
	Q92817
	Q9D952
	NM_001988; NM_001320747
	NM_025276
	NP_001307676; NP_001979; NP_001307676.1
	NP_079552
	위키다타
인간 보기/편집	마우스 보기/편집

엔보플라킨은 인간에게 EVPL 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

상호작용

Envoplakin은 PPL과 상호작용하는 것으로 나타났다.^[8]^[9]

참고 항목

펨피거스의 표적항원 목록

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000167880 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000034282 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ruhrberg C, Williamson JA, Sheer D, Watt FM (Mar 1997). "Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25". Genomics. 37 (3): 381–5. doi:10.1006/geno.1996.0573. PMID 8938451.
^ Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK (Sep 1999). "Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25". Genomics. 59 (2): 234–42. doi:10.1006/geno.1999.5857. PMID 10409435.
^ "Entrez Gene: EVPL envoplakin".
^ Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088.
^ Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC 2132639. PMID 9412476.

추가 읽기

Ruhrberg C, Hajibagheri MA, Simon M, et al. (1996). "Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin". J. Cell Biol. 134 (3): 715–29. doi:10.1083/jcb.134.3.715. PMC 2120946. PMID 8707850.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
Robinson NA, Lapic S, Welter JF, Eckert RL (1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". J. Biol. Chem. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM (1998). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. PMC 2132639. PMID 9412476.
Marekov LN, Steinert PM (1998). "Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope". J. Biol. Chem. 273 (28): 17763–70. doi:10.1074/jbc.273.28.17763. PMID 9651377.
Määttä A, Ruhrberg C, Watt FM (2000). "Structure and regulation of the envoplakin gene". J. Biol. Chem. 275 (26): 19857–65. doi:10.1074/jbc.M001028200. PMID 10747979.
Lee CH, Marekov LN, Kim S, et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Lett. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733. S2CID 12228606.
DiColandrea T, Karashima T, Määttä A, Watt FM (2000). "Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope". J. Cell Biol. 151 (3): 573–86. doi:10.1083/jcb.151.3.573. PMC 2185584. PMID 11062259.
Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. PMID 12366696. S2CID 25735126.
Karashima T, Watt FM (2003). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. PMID 12432088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kalinin AE, Idler WW, Marekov LN, et al. (2004). "Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia". J. Biol. Chem. 279 (21): 22773–80. doi:10.1074/jbc.M313660200. PMID 15033990.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Iwaya T, Maesawa C, Kimura T, et al. (2005). "Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas". Oncol. Rep. 13 (4): 703–7. doi:10.3892/or.13.4.703. PMID 15756445.

17번 염색체의 유전자에 관한 이 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000167880 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000034282 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8938451-5] Ruhrberg C, Williamson JA, Sheer D, Watt FM (Mar 1997). "Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25". Genomics. 37 (3): 381–5. doi:10.1006/geno.1996.0573. PMID 8938451.

[pmid10409435-6] Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK (Sep 1999). "Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25". Genomics. 59 (2): 234–42. doi:10.1006/geno.1999.5857. PMID 10409435.

[entrez-7] "Entrez Gene: EVPL envoplakin".

[pmid12432088-8] Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24): 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088.

[pmid9412476-9] Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7): 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC 2132639. PMID 9412476.

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엔보플라킨

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상호작용

참고 항목

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