미오신-2

MYH2
식별자
에일리어스	MYH2, IBM3, MYH2A, MYHSA2, MYHAS8, MyHC-2A, MyHC-IA, MYPOP, 마이신, 헤비체인 2, 골격근, 성인, 마이신 헤비체인 2
외부 ID	OMIM : 160740 MGI : 1339710 HomoloGene : 23019 GeneCard : MYH2
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	10,549,700 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	67,088,343 bp
RNA발현패턴
	상단 표시 위치:
	설체; ; 외측 광대근; ; 흉부 횡격막; ; 상완 삼두근; ; 삼각근; ; 위근; ; 정강이뼈전근; ; 후두; ; 혀 윗면; ; 구강;
	상단 표시 위치:
	발바닥근; ; 늑간근; ; 흉골윤활근; ; 발목; ; 안마근; ; 측두근; ; 안외근; ; 이복근; ; 외측 광대근; ; 대퇴골체;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	뉴클레오티드 결합; 액틴 결합; 마이크로필라멘트 운동 활성; 단백질 결합; 세포골격운동활성; ATP 결합; 칼모듈린 결합; 액틴 필라멘트 결합; 미소관 운동 활성; 미소관 결합;
셀룰러 컴포넌트	세포질; 미오신 필라멘트; 세포; 근섬유; 서커머; 미오신 착화체; 밴드; 단백질 함유 복합체; 골지 장치; 악토미오신수축환; 근미오신복합체; 세포-세포 접합;
생물학적 과정	식세포증에 관여하는 Fc-gamma 수용체 시그널링 경로; 근육 필라멘트 슬라이딩; 미소관에 의한 운동; 혈장막 복구; 근육 수축; 활동에 대한 반응; 액틴분해세포수축;
	출처:아미고 / QuickGO
맞춤법
	4620
	17882
	ENSG00000125414
	ENSMUSG000033196
	Q9UKX2
	G3UW82
	NM_017534; NM_001100112
	NM_001039545; NM_144961
	NP_001093582; NP_060004
	NP_001034634
	위키데이터
인간 보기/편집	마우스 표시/편집

미오신-2(미오신 중쇄 2)는 인간의 MYH2 ^[5]^[6]유전자에 의해 암호화되는 단백질이다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000125414 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000033196 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID 7545970.
^ "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

추가 정보

Schwartz CE, McNally E, Leinwand L, Skolnick MH (1987). "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13". Cytogenet. Cell Genet. 43 (1–2): 117–20. doi:10.1159/000132307. PMID 2877813.
Ennion S, Sant'ana Pereira J, Sargeant AJ, et al. (1995). "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express". J. Muscle Res. Cell. Motil. 16 (1): 35–43. doi:10.1007/BF00125308. PMID 7751403. S2CID 22270940.
Hisatome I, Morisaki T, Kamma H, et al. (1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870–81. doi:10.1152/ajpcell.1998.275.3.C870. PMID 9730972.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Onuoha GN, Alpar EK, Laprade M, et al. (1999). "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle". Clinical and Investigative Medicine. 22 (5): 180–4. PMID 10579056.
Martinsson T, Oldfors A, Darin N, et al. (2001). "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614–9. doi:10.1073/pnas.250289597. PMC 18967. PMID 11114175.
Tajsharghi H, Thornell LE, Darin N, et al. (2002). "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age". Neurology. 58 (5): 780–6. doi:10.1212/wnl.58.5.780. PMID 11889243. S2CID 31098150.
England K, Ashford D, Kidd D, Rumsby M (2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. PMID 11897493.
Allen DL, Leinwand LA (2003). "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter". J. Biol. Chem. 277 (47): 45323–30. doi:10.1074/jbc.M208302200. PMID 12235157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim EJ, Helfman DM (2003). "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem. 278 (32): 30063–73. doi:10.1074/jbc.M304909200. PMID 12756252.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chung MC, Kawamoto S (2005). "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation". J. Biol. Chem. 279 (53): 56042–52. doi:10.1074/jbc.M404791200. PMID 15496418.
Tajsharghi H, Darin N, Rekabdar E, et al. (2005). "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)". Eur. J. Hum. Genet. 13 (5): 617–22. doi:10.1038/sj.ejhg.5201375. PMID 15741996.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Li M, Lionikas A, Yu F, et al. (2006). "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)". Neuromuscul. Disord. 16 (11): 782–91. doi:10.1016/j.nmd.2006.07.023. PMC 1693964. PMID 17005402.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

인간 염색체 17번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000125414 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000033196 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7545970-5] Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID 7545970.

[entrez-6] "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

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