활성C인산화효소1수용체

Receptor for activated C kinase 1
랙 1
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스RACK1, Gnb2-rs1, H12.3, HLC-7, PIG21, GNB2L1, 활성 C인산화효소1 수용체
외부 IDOMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCard: RACK1
맞춤법
종.인간마우스
엔트레즈

10399

14694

앙상블

ENSG00000204628

ENSMUSG000020372

유니프로트

P63244

P68040

RefSeq(mRNA)

NM_006098

NM_008143

RefSeq(단백질)

NP_006089

NP_032169

장소(UCSC)Chr 5: 181.24 ~181.25 MbChr 11: 48.69 ~48.7 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

구아닌 뉴클레오티드 결합 단백질 서브유닛 베타-2-라이크 1(GNB2L1)이라고도 알려진 활성 C인산화효소 1(RACK1) 수용체는 인간에서 RACK1 [5][6]유전자에 의해 암호화되는 35kDa 단백질이다.

기능.

RACK1은 원래 단백질 키나제 C에 대한 세포 내 단백질 수용체로 분리되었고, 헤테로리머 G [5]단백질의 베타 서브유닛에 대한 유의한 호몰로지에 주목하였다.이후 연구는 RACK1과 그 효모 상동성 Asc1을 진핵생물 소([7][8][9]40S) 리보솜 서브유닛의 핵심 리보솜 단백질로 확립했다.Asc1/RACK1의 기능 대부분은 40S 리보솜 서브유닛의 '[10]헤드'에 위치하기 때문에 발생하는 것으로 보인다.Asc1/RACK1은 IRES 매개 번역,[11] 논스톱 붕괴,[12] 비기능성 18S 리보솜 RNA [13]붕괴 및 프레임시프트를 [14]포함한 진핵생물 번역 및 리보솜 품질 제어의 여러 측면에 관여한다.

상호 작용

RACK1은 40S 리보솜 서브유닛의 용제노출표면에 위치하여 18S rRNA 및 US3, US9 및 eS17을 포함한 다른 리보솜 단백질과의 접촉을 통해 제자리에 고정된다.또한 RACK1은 다음 제품과 상호 작용하는 것으로 나타났습니다.

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레퍼런스

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