PDE4D
PDE4D
cAMP 특이적 3', 5'-순환 포스포디에스테라아제 4D는 PDE4D 유전자에 의해 인체 내에서 코드되는 효소이다.
기능.
PDE4D 유전자는 복잡하고 기능성 단백질을 코드하는 최소 9개의 다른 동질 형태를 가지고 있다.이러한 단백질은 혈관 세포를 포함한 여러 세포 유형의 핵심 신호 전달 분자인 두 번째 메신저 cAMP를 분해한다(Dominiczak and McBride, 2003).[OMIM [3]제공]
상호 작용
PDE4D는 미오메갈린[4] 및 GNB2L1과 [5][6]상호작용하는 것으로 나타났다.
임상 관련성
이 유전자의 돌연변이는 무좀증 [7]사례와 연관되어 왔다.
이는 PDE4 억제제의 [8]구토 및 항우울제 효과에 관여하는 것으로 보이는 PDE4의 아형이다.
또한 전립선암 바이오마커로서 아이소폼 PDE4D7의 발현 변화가 제안되었다.[9] [10] [11]
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000113448 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (Apr 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal of Biological Chemistry. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006.
- ^ Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". The Journal of Biological Chemistry. 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691.
- ^ Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling. 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626.
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- ^ Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current Pharmaceutical Design. 15 (14): 1688–98. doi:10.2174/138161209788168092. PMID 19442182.
- ^ Böttcher R, Henderson DJ, Dulla K, van Strijp D, Waanders LF, Tevz G, Lehman ML, Merkle D, van Leenders GJ, Baillie GS, Jenster G, Houslay MD, Hoffmann R (Nov 2015). "Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression". British Journal of Cancer. 113 (10): 1502–11. doi:10.1038/bjc.2015.335. PMC 4815894. PMID 26575822.
- ^ Böttcher R, Dulla K, van Strijp D, Dits N, Verhoef EI, Baillie GS, van Leenders GJ, Houslay MD, Jenster G, Hoffmann R (Oct 2016). "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases". Oncotarget. 7 (43): 70669–70684. doi:10.18632/oncotarget.12204. PMC 5342582. PMID 27683107.
- ^ Henderson DJ, Byrne A, Dulla K, Jenster G, Hoffmann R, Baillie GS, Houslay MD (Mar 2014). "The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells". British Journal of Cancer. 110 (5): 1278–87. doi:10.1038/bjc.2014.22. PMC 3950871. PMID 24518597.
추가 정보
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- Böttcher R, Dulla K, van Strijp D, Dits N, Verhoef EI, Baillie GS, van Leenders GJ, Houslay MD, Jenster G, Hoffmann R (Oct 2016). "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases". Oncotarget. 7 (43): 70669–70684. doi:10.18632/oncotarget.12204. PMC 5342582. PMID 27683107.
- Henderson DJ, Byrne A, Dulla K, Jenster G, Hoffmann R, Baillie GS, Houslay MD (Mar 2014). "The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells". British Journal of Cancer. 110 (5): 1278–87. doi:10.1038/bjc.2014.22. PMC 3950871. PMID 24518597.
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