EIF5A

EIF5A
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3CPF, 5DLQ
식별자
에일리어스	EIF5A, EIF-5A, EIF5A1, eIF5AI, 진핵생물 번역 개시인자 5A, eIF-4D, FABAS
외부 ID	OMIM : 600187 MGI : 106248 HomoloGene : 133803 GenCard : EIF5A
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	7,312,463 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	69,812,784 bp
RNA발현패턴
	상단 표시 위치:
	복부 피부; ; 자궁내막간질세포; ; 부록; ; 위근; ; 랑게르한스 섬; ; 우부신; ; 좌부신; ; 태반; ; 췌장체; ; 림프절;
	상단 표시 위치:
	소마이트; ; 원시적 특징; ; 손; ; 진피; ; 상악 융기; ; 복벽; ; 아트리움; ; 모낭; ; 소장의 리베르쿤 지하실; ; 송과선;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 N말단결합; 리보솜 결합; 번역 신장 인자 활성; 단백질 결합; RNA결합; U6 snRNA 바인딩;
셀룰러 컴포넌트	세포질; 세포; 소포체막; 막; 핵공; 고리 모양의 층상; 소포체; 세포외 엑소좀; 핵; 수상돌기; 신경세포체;
생물학적 과정	mRNA 트랜스포트; 단백질생합성; 병진 신장 양의 조절; 병진 신장; 핵으로부터의 mRNA 내보내기; 펩티딜-피루신으로의 펩티딜-피루신 수식; 핵세포질수송; 핵으로부터의 단백질 수출; 세포군 증식의 양성 조절; 단백질 수송; 변환 프레임 시프트; 번역 종료의 정의 조절; 아포토시스 과정; 세포질 칼슘 이온 농도 양성 조절; 에이징; 심근 세포 아포토시스 과정의 양성 조절; 아포토시스 과정의 양성 조절; 아포토시스 과정의 음성 조절; 근육 세포 분화의 양성 조절; 갑상선 호르몬 자극에 대한 세포 반응; 활성산소종 대사과정 양성조절; 운송;
	출처:아미고 / QuickGO
맞춤법
	1984
	276770
	ENSG00000132507; ENSG00000288145
	ENSMUSG000078812
	P63241
	P63242
NM_001143760; NM_001143761; NM_001143762; NM_001970; NM_001370420;
	NM_001370421
NM_001166589; NM_001166590; NM_001166591; NM_001166592; NM_001166593;
	NM_001166594; NM_001166595; NM_001166596; NM_181582
NP_001137232; NP_001137233; NP_001137234; NP_001961; NP_001357349;
	NP_001357350
NP_001160061; NP_001160062; NP_001160063; NP_001160064; NP_001160065;
	NP_001160066; NP_001160067; NP_001160068; NP_853613
	위키데이터
인간 보기/편집	마우스 표시/편집

진핵생물번역개시인자 5A-1은 EIF5A 유전자에 ^[5]의해 인체 내에서 암호화되는 단백질이다.

폴리아민 스펠미딘의 특정 리신 잔기로 eIF5A에서 두 가지 촉매 ^[6]단계로 합성되는 특이 아미노산 하이푸신 [N-^ε(4-아미노-2-히드록시부틸)-리신]을 함유하는 유일한 단백질이다.

EF-P는 eIF5A의 박테리아 상동성으로, 번역 후 유사하지만 뚜렷한 방식으로 ^[7]^[8]변형됩니다.두 단백질 모두 펩타이드 결합 형성을 촉매하고 리보솜 막힘을 해결하는 데 도움을 주는 것으로 믿어지며, 원래 ^[9]"개시 인자"라는 명칭에도 불구하고 신장 인자가 된다.

임상 관련성

생식계 유해 헤테로 접합 EIF5A 변종은 Faundes-Banka ^[10]^[11]증후군을 일으킨다.이 희귀한 인간 질환은 발달 지연, 소두증, 소두증, 소두증 및 비정형 특징의 다양한 조합으로 특징지어진다.

레퍼런스

^ ^a ^b ^c ENSG00000288145 GRCh38: 앙상블 릴리즈 89: ENSG00000132507, ENSG00000288145 - Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000078812 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Steinkasserer A, Jones T, Sheer D, Koettnitz K, Hauber J, Bevec D (February 1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.
^ Wolff EC, Kang KR, Kim YS, Park MH (August 2007). "Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification". Amino Acids. 33 (2): 341–350. doi:10.1007/s00726-007-0525-0. PMC 2572820. PMID 17476569.
^ Park JH, Johansson HE, Aoki H, Huang BX, Kim HY, Ganoza MC, Park MH (January 2012). "Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)". The Journal of Biological Chemistry. 287 (4): 2579–2590. doi:10.1074/jbc.M111.309633. PMC 3268417. PMID 22128152.
^ Peil L, Starosta AL, Virumäe K, Atkinson GC, Tenson T, Remme J, Wilson DN (August 2012). "Lys34 of translation elongation factor EF-P is hydroxylated by YfcM". Nature Chemical Biology. 8 (8): 695–697. doi:10.1038/nchembio.1001. PMID 22706199.
^ Rossi D, Kuroshu R, Zanelli CF, Valentini SR (2013). "eIF5A and EF-P: two unique translation factors are now traveling the same road". Wiley Interdisciplinary Reviews. RNA. 5 (2): 209–222. doi:10.1002/wrna.1211. PMID 24402910. S2CID 25447826.
^ Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AG, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S (February 2021). "Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine". Nature Communications. 12 (1): 833. Bibcode:2021NatCo..12..833F. doi:10.1038/s41467-021-21053-2. PMC 7864902. PMID 33547280.
^ "OMIM Entry - # 619376 - FAUNDES-BANKA SYNDROME; FABAS". omim.org. Retrieved 2022-01-03.

추가 정보

Bevec D, Hauber J (1997). "Eukaryotic initiation factor 5A activity and HIV-1 Rev function". Biological Signals. 6 (3): 124–133. doi:10.1159/000109118. PMID 9285095.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–934. doi:10.1038/sj.cr.7290370. PMID 16354571.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
Chung SI, Park MH, Folk JE, Lewis MS (February 1991). "Eukaryotic initiation factor 5A: the molecular form of the hypusine-containing protein from human erythrocytes". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1076 (3): 448–451. doi:10.1016/0167-4838(91)90490-q. PMID 1900436.
Smit-McBride Z, Dever TE, Hershey JW, Merrick WC (January 1989). "Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein". The Journal of Biological Chemistry. 264 (3): 1578–1583. doi:10.1016/S0021-9258(18)94226-2. PMID 2492279.
Park MH, Liu TY, Neece SH, Swiggard WJ (November 1986). "Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue". The Journal of Biological Chemistry. 261 (31): 14515–14519. doi:10.1016/S0021-9258(18)66899-1. PMID 3095320.
Koettnitz K, Kappel B, Baumruker T, Hauber J, Bevec D (July 1994). "The genomic structure encoding human initiation factor eIF-5A". Gene. 144 (2): 249–252. doi:10.1016/0378-1119(94)90385-9. PMID 7545941.
Klier H, Csonga R, Joäo HC, Eckerskorn C, Auer M, Lottspeich F, Eder J (November 1995). "Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells". Biochemistry. 34 (45): 14693–14702. doi:10.1021/bi00045a010. PMID 7578077.
Koettnitz K, Wöhl T, Kappel B, Lottspeich F, Hauber J, Bevec D (July 1995). "Identification of a new member of the human eIF-5A gene family". Gene. 159 (2): 283–284. doi:10.1016/0378-1119(95)00136-T. PMID 7622067.
Joe YA, Park MH (October 1994). "Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine". The Journal of Biological Chemistry. 269 (41): 25916–25921. doi:10.1016/S0021-9258(18)47333-4. PMID 7929297.
Bevec D, Klier H, Holter W, Tschachler E, Valent P, Lottspeich F, et al. (November 1994). "Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 91 (23): 10829–10833. Bibcode:1994PNAS...9110829B. doi:10.1073/pnas.91.23.10829. PMC 45119. PMID 7971969.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, Wolff B, et al. (December 1993). "Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation". The Journal of Cell Biology. 123 (6 Pt 1): 1309–1320. doi:10.1083/jcb.123.6.1309. PMC 2290910. PMID 8253832.
Liu YP, Nemeroff M, Yan YP, Chen KY (1997). "Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification". Biological Signals. 6 (3): 166–174. doi:10.1159/000109123. PMID 9285100.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Singh US, Li Q, Cerione R (January 1998). "Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II". The Journal of Biological Chemistry. 273 (4): 1946–1950. doi:10.1074/jbc.273.4.1946. PMID 9442029.
Schatz O, Oft M, Dascher C, Schebesta M, Rosorius O, Jaksche H, et al. (February 1998). "Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5". Proceedings of the National Academy of Sciences of the United States of America. 95 (4): 1607–1612. Bibcode:1998PNAS...95.1607S. doi:10.1073/pnas.95.4.1607. PMC 19115. PMID 9465063.
Lee YB, Joe YA, Wolff EC, Dimitriadis EK, Park MH (May 1999). "Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor". The Biochemical Journal. 340 (1): 273–281. doi:10.1042/0264-6021:3400273. PMC 1220246. PMID 10229683.

인간 염색체 17번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000288145 GRCh38: 앙상블 릴리즈 89: ENSG00000132507, ENSG00000288145 - Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000078812 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7759117-5] Steinkasserer A, Jones T, Sheer D, Koettnitz K, Hauber J, Bevec D (February 1995). "The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2". Genomics. 25 (3): 749–752. doi:10.1016/0888-7543(95)80025-H. PMID 7759117.

[pmid17476569-6] Wolff EC, Kang KR, Kim YS, Park MH (August 2007). "Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification". Amino Acids. 33 (2): 341–350. doi:10.1007/s00726-007-0525-0. PMC 2572820. PMID 17476569.

[pmid22128152-7] Park JH, Johansson HE, Aoki H, Huang BX, Kim HY, Ganoza MC, Park MH (January 2012). "Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)". The Journal of Biological Chemistry. 287 (4): 2579–2590. doi:10.1074/jbc.M111.309633. PMC 3268417. PMID 22128152.

[pmid22706199-8] Peil L, Starosta AL, Virumäe K, Atkinson GC, Tenson T, Remme J, Wilson DN (August 2012). "Lys34 of translation elongation factor EF-P is hydroxylated by YfcM". Nature Chemical Biology. 8 (8): 695–697. doi:10.1038/nchembio.1001. PMID 22706199.

[pmid24402910-9] Rossi D, Kuroshu R, Zanelli CF, Valentini SR (2013). "eIF5A and EF-P: two unique translation factors are now traveling the same road". Wiley Interdisciplinary Reviews. RNA. 5 (2): 209–222. doi:10.1002/wrna.1211. PMID 24402910. S2CID 25447826.

[10] Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AG, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S (February 2021). "Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine". Nature Communications. 12 (1): 833. Bibcode:2021NatCo..12..833F. doi:10.1038/s41467-021-21053-2. PMC 7864902. PMID 33547280.

[11] "OMIM Entry - # 619376 - FAUNDES-BANKA SYNDROME; FABAS". omim.org. Retrieved 2022-01-03.

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EIF5A

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임상 관련성

레퍼런스

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