호모 사피엔스 종의 단백질 코드 유전자
진핵생물번역개시인자 1A , X염색체 (eIF1A)는 EIF1AX [5] [6] [7] 단백질 이다.이 유전자는 필수 진핵생물 번역 개시 인자를 암호화한다. 단백질은 43S 사전 개시 복합체 (PIC)의 구성 요소이며, 이는 [7] RNA 의 5' 캡에 대한 작은 40S 리보솜 서브유닛의 신병을 중개한다.
기능. eIF1A는 작은 단백질(발아 효모의 경우 17kDa)로 43S 사전 개시 복합체(PIC)의 구성 요소이며, 기능적으로 관련된 세균상대물 [8] 부위 근처에 결합한다.
임상적 의의 이 유전자의 돌연변이는 디소미를 가진 포도막 흑색종 증례와 동시에 관련되어 있다.3.[9] 갑상선암 에서 [10]
상호 작용 EIF1AX는 IPO13 과 [11] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000173674 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000057561 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing" . The Journal of Biological Chemistry . 269 (5): 3212–8. doi :10.1016/S0021-9258(17)41850-3 PMID 8106356 . ^ Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science . 278 (5338): 675–80. Bibcode :1997Sci...278..675L . doi :10.1126/science.278.5338.675 . PMID 9381176 . ^ a b "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked" .^ Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome" . Biochimie . 114 : 58–71. doi :10.1016/j.biochi.2015.02.017 . PMC 4458453 PMID 25742741 . ^ Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M (Aug 2013). "Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3" . Nature Genetics . 45 (8): 933–6. doi :10.1038/ng.2674 . PMC 4307600 PMID 23793026 . ^ Xu, Yichen; Ruggero, Davide (2020-03-09). "The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications" . Annual Review of Cancer Biology . 4 (1): 437–457. doi :10.1146/annurev-cancerbio-030419-033420 ISSN 2472-3428 . ^ Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export" . The EMBO Journal . 20 (14): 3685–94. doi :10.1093/emboj/20.14.3685 . 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외부 링크 PDB for UniProt: P47813 PDB 에서 사용할 수 있는 모든 구조 정보의 개요.
